A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1 - Cevikbas, Ferda; Wang, Xidao; Akiyama, Tasuku; Kempkes, Cordula; Savinko, Terhi; Antal, Attila; Kukova, Gabriela; Buhl, Timo; Ikoma, Akihiko; Buddenkotte, Joerg; Soumelis, Vassili; Feld, Micha; et al. (Journal of allergy and clinical immunology, 2014)
Keywords: Allergic diseases; Allergy and Immunology; Animals; atopic dermatitis; Biological and medical sciences; Calcium Channels - immunology; Cell culture; Cells, Cultured; Cytokine; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Ganglia, Spinal - cytology; Human subjects; Humans; Immunopathology; Interleukins - immunology; Lymphoma; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineral oils; Nerve Tissue Proteins - immunology; Neurons; Pruritus - immunology; Psoriasis; Receptors, Interleukin - genetics; Receptors, Interleukin - immunology; Rodents; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; sensory nerve; Sensory Receptor Cells - immunology; skin; Skin - immunology; Skin allergic diseases. Stinging insect allergies; Skin diseases; Spinal cord; Th2 Cells - immunology; transient receptor potential channel; Transient Receptor Potential Channels - immunology; TRPA1 Cation Channel; TRPV Cation Channels - genetics; TRPV Cation Channels - immunology; skin; atopic dermatitis; AITC; OSMRβ; GRPR; SC; qPCR; transient receptor potential channel; hpf; PAR-2; AD; KO; TRPA1; Cytokine; TRPV1; SEB; MEK; TG; NPR-A; Mrgpr; sensory nerve; DRG; IB4; HBSS; OVA; ERK; Spinal cord; Proteinase-activated receptor 2; Oncostatin M receptor β; Allyl isothiocyanate; Natriuretic peptide receptor A; Mitogen-activated protein kinase enzyme; Dorsal root ganglia; Ovalbumin; Quantitative real-time PCR; Transient receptor channel potential cation channel ankyrin subtype 1; High-power field; Extracellular signal-regulated kinase; Transient receptor potential cation channel vanilloid subtype 1; Mas-related G protein–coupled receptor; Knockout; Gastrin-releasing peptide receptor; Hanks balanced salt solution; Isolectin B4; Staphylococcal enterotoxin B; Trigeminal ganglion; Allergy; Immunopathology; Skin disease; Helper cell; Ionic channel; Pruritus; Transitory; Atopy; Immunology; Neuron