Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 33; pp. 14875 - 14880
• Main Authors: Horvath, Tamas L., Sarman, Beatrix, García-Cáceres, Cristina, Enriori, Pablo J., Sotonyi, Peter, Shanabrough, Marya, Borok, Erzsebet, Argente, Jesus, Chowen, Julie A., Perez-Tilve, Diego, Pfluger, Paul T., Brönneke, Hella S., Levin, Barry E., Diano, Sabrina, Cowley, Michael A., Tschöp, Matthias H., Friedman, Jeffrey M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.08.2010; National Acad Sciences
• Subjects: Animals; Arcuate nucleus; Arcuate Nucleus of Hypothalamus - metabolism; Arcuate Nucleus of Hypothalamus - pathology; Arcuate Nucleus of Hypothalamus - physiopathology; Biological Sciences; Blood vessels; Blood-brain barrier; Body weight; Brain; Brain architecture; Cell body; Cells; Circuits; Data processing; Dendrites; Diet; Dietary Fats - adverse effects; Diets; Energy expenditure; Feeding behavior; Female; Gliosis; Gliosis - etiology; Gliosis - metabolism; High fat diet; Hypothalamus; Hypothalamus - metabolism; Hypothalamus - pathology; Hypothalamus - physiopathology; Immunohistochemistry; Male; Melanocortin; Melanocortins; Melanocortins - metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron; Neuroglia; Neuronal-glial interactions; Neurons; Neurons - metabolism; Neurons - ultrastructure; Neuropeptide Y; Neuropeptide Y - metabolism; Obesity; Obesity - etiology; Obesity - metabolism; Peptides; pro-opiomelanocortin; Pro-Opiomelanocortin - metabolism; Proopiomelanocortin; Rats; Rats, Sprague-Dawley; Rodents; Synapses; Synapses - metabolism; Synaptic Transmission - physiology; vulnerability

The neuronal circuits involved in the regulation of feeding behavior and energy expenditure are soft-wired, reflecting the relative activity of the postsynaptic neuronal system, including the anorexigenic proopiomelanocortin (POMC)-expressing cells of the arcuate nucleus. We analyzed the synaptic in...