Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity - Horvath, Tamas L.; Sarman, Beatrix; García-Cáceres, Cristina; Enriori, Pablo J.; Sotonyi, Peter; Shanabrough, Marya; Borok, Erzsebet; Argente, Jesus; Chowen, Julie A.; Perez-Tilve, Diego; Pfluger, Paul T.; Brönneke, Hella S.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2010)
Keywords: Animals; Arcuate nucleus; Arcuate Nucleus of Hypothalamus - metabolism; Arcuate Nucleus of Hypothalamus - pathology; Arcuate Nucleus of Hypothalamus - physiopathology; Biological Sciences; Blood vessels; Blood-brain barrier; Body weight; Brain; Brain architecture; Cell body; Cells; Circuits; Data processing; Dendrites; Diet; Dietary Fats - adverse effects; Diets; Energy expenditure; Feeding behavior; Female; Gliosis; Gliosis - etiology; Gliosis - metabolism; High fat diet; Hypothalamus; Hypothalamus - metabolism; Hypothalamus - pathology; Hypothalamus - physiopathology; Immunohistochemistry; Male; Melanocortin; Melanocortins; Melanocortins - metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron; Neuroglia; Neuronal-glial interactions; Neurons; Neurons - metabolism; Neurons - ultrastructure; Neuropeptide Y; Neuropeptide Y - metabolism; Obesity; Obesity - etiology; Obesity - metabolism; Peptides; pro-opiomelanocortin; Pro-Opiomelanocortin - metabolism; Proopiomelanocortin; Rats; Rats, Sprague-Dawley; Rodents; Synapses; Synapses - metabolism; Synaptic Transmission - physiology; vulnerability