Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria

• Published in: BMC microbiology Vol. 21; no. 1; pp. 235 - 7
• Main Authors: Tsunematsu, Yuta, Hosomi, Koji, Kunisawa, Jun, Sato, Michio, Shibuya, Noriko, Saito, Emiko, Murakami, Haruka, Yoshikawa, Yuko, Iwashita, Yuji, Miyoshi, Noriyuki, Mutoh, Michihiro, Ishikawa, Hideki, Sugimura, Haruhiko, Miyachi, Motohiko, Wakabayashi, Keiji, Watanabe, Kenji
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.08.2021; BioMed Central; BMC
• Subjects: Babies; Bacterial toxins; Bacterial Toxins - biosynthesis; Birth; Breast feeding; Breastfeeding & lactation; Carcinogenesis; Carcinogens; Carcinogens - analysis; Carcinogens - metabolism; Cesarean section; Childbirth & labor; Colibactin; Coliforms; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - etiology; Colorectal Neoplasms - microbiology; E coli; Escherichia coli; Escherichia coli - chemistry; Escherichia coli - metabolism; Escherichia coli - pathogenicity; Escherichia coli infections; Escherichia coli Infections - complications; Escherichia coli Infections - microbiology; Escherichia coli Infections - transmission; Feces; Feces - microbiology; Female; Food; Food intake; Genotoxicity; Health aspects; Human subjects; Humans; Infant, Newborn; Infants; Infections; Infectious Disease Transmission, Vertical; Male; Metabolites; Mothers; Natural product; Newborn babies; Peptides - analysis; Peptides - genetics; Peptides - metabolism; Perinatal infection; Perinatal transmission; Polyketides - analysis; Polyketides - metabolism; Risk factors; Toxins; Tumorigenesis; Vagina; Japan; Natural product; Colibactin; Perinatal transmission; Escherichia coli; Colorectal cancer

The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportuniti...