Exendin-4 Protects Against Sulfonylurea-Induced β-Cell Apoptosis

• Published in: Journal of Pharmacological Sciences Vol. 118; no. 1; pp. 65 - 74
• Main Authors: Kim, Ju-Young, Lim, Dong-Mee, Park, Hyung-Seo, Moon, Chan-Il, Choi, Kyung-Jin, Lee, Seong-Kyu, Baik, Haing-Woon, Park, Keun-Young, Kim, Byung-Joon
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 2012; The Japanese Pharmacological Society; Elsevier
• Subjects: Animals; apoptosis; Apoptosis - drug effects; Calcium - metabolism; Cell Line; Cricetinae; endoplasmic reticulum (ER) calcium depletion; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum Stress - drug effects; ER stress; Exenatide; glucagon like peptide-1(GLP-1); Glucagon-Like Peptide 1 - agonists; Glyburide - adverse effects; Hypoglycemic Agents - adverse effects; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Peptides - pharmacology; Rats; Rats, Sprague-Dawley; sulfonylurea; Venoms - pharmacology; ER stress; endoplasmic reticulum (ER) calcium depletion; sulfonylurea; apoptosis; glucagon like peptide-1(GLP-1)

Sulfonylurea is one of the commonly used anti-diabetic drugs that stimulate insulin secretion from β-cells. Despite their glucose lowering effects in type 2 diabetes mellitus, long-term treatment brought on secondary failure characterized by β-cell exhaustion and apoptosis. ER stress induced by Ca2+...