Thrombospondin‐1 Regulates Trophoblast Necroptosis via NEDD4‐Mediated Ubiquitination of TAK1 in Preeclampsia

• Published in: Advanced science Vol. 11; no. 21; pp. e2309002 - n/a
• Main Authors: Hu, Haoyue, Ma, Jing, Peng, You, Feng, Rixuan, Luo, Chenling, Zhang, Minyi, Tao, Zixin, Chen, Lu, Zhang, Tao, Chen, Wenqian, Yin, Qian, Zhai, Jinguo, Chen, Jun, Yin, Ailan, Wang, Chi Chiu, Zhong, Mei
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.06.2024; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Blood pressure; Enzymes; Female; Humans; Inflammation; Kinases; MAP Kinase Kinase Kinases - genetics; MAP Kinase Kinase Kinases - metabolism; necroptosis; Necroptosis - genetics; Nedd4 Ubiquitin Protein Ligases - genetics; Nedd4 Ubiquitin Protein Ligases - metabolism; Pathogenesis; Placenta; Placenta - metabolism; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Proteins; Proteomics; Thrombospondin 1 - genetics; Thrombospondin 1 - metabolism; thrombospondin‐1; trophoblast; Trophoblasts - metabolism; Ubiquitination; thrombospondin‐1; preeclampsia; trophoblast; ubiquitination; necroptosis

Preeclampsia (PE) is considered as a disease of placental origin. However, the specific mechanism of placental abnormalities remains elusive. This study identified thrombospondin‐1 (THBS1) is downregulated in preeclamptic placentae and negatively correlated with blood pressure. Functional studies sh...