Dual‐Mechanism Peptide SR25 has Broad Antimicrobial Activity and Potential Application for Healing Bacteria‐infected Diabetic Wounds

The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram‐negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram‐negative and Gram‐...

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Published inAdvanced science Vol. 11; no. 30; pp. e2401793 - n/a
Main Authors Luo, Xue‐Yue, Hu, Chun‐Mei, Yin, Qi, Zhang, Xiao‐Mei, Liu, Zhen‐Zhen, Zhou, Cheng‐Kai, Zhang, Jian‐Gang, Chen, Wei, Yang, Yong‐Jun
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.08.2024
John Wiley and Sons Inc
Wiley
Subjects
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobial agents
antimicrobial peptides
Antimicrobial Peptides - pharmacology
Bacteria
Bacterial infections
Biocompatibility
Biofilms
Dairy cattle
Diabetes
Diabetes Mellitus, Experimental - drug therapy
diabetic wound
Disease Models, Animal
Drug resistance
E coli
Escherichia coli - drug effects
Genomes
hydrogel
Hydrogels
Listeria
membrane disrupting
Methicillin-Resistant Staphylococcus aureus - drug effects
Mice
Microbial Sensitivity Tests
Natural products
Peptides
Physiology
Salmonella
Staphylococcus infections
succinate:quinone reductase
uncultured bacteria
Wound Healing - drug effects
Wound Infection - drug therapy
Wound Infection - microbiology
membrane disrupting
diabetic wound
hydrogel
succinate:quinone reductase
antimicrobial peptides
uncultured bacteria
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Abstract The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram‐negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram‐negative and Gram‐positive bacteria through a unique dual‐targeting mechanism without detectable resistance. Meanwhile, an SR25‐functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25‐incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli (E. coli) and methicillin‐resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens. The previously uncultured bacterium presents a viable strategy for the discovery of novel antimicrobial peptides. The antimicrobial peptide SR25 operates through a dual mechanism, targeting both the bacterial cell membrane and succinate:quinone oxidoreductase. It exhibits outstanding antibacterial efficacy and promotes the recovery of infected diabetes wounds.
AbstractList Abstract The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram‐negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram‐negative and Gram‐positive bacteria through a unique dual‐targeting mechanism without detectable resistance. Meanwhile, an SR25‐functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25‐incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli (E. coli) and methicillin‐resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens.
The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram-negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism without detectable resistance. Meanwhile, an SR25-functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25-incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens.
The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram‐negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram‐negative and Gram‐positive bacteria through a unique dual‐targeting mechanism without detectable resistance. Meanwhile, an SR25‐functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25‐incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli ( E. coli ) and methicillin‐resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens. The previously uncultured bacterium presents a viable strategy for the discovery of novel antimicrobial peptides. The antimicrobial peptide SR25 operates through a dual mechanism, targeting both the bacterial cell membrane and succinate:quinone oxidoreductase. It exhibits outstanding antibacterial efficacy and promotes the recovery of infected diabetes wounds.
The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram-negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism without detectable resistance. Meanwhile, an SR25-functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25-incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens.The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram-negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism without detectable resistance. Meanwhile, an SR25-functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25-incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens.
The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram‐negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram‐negative and Gram‐positive bacteria through a unique dual‐targeting mechanism without detectable resistance. Meanwhile, an SR25‐functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25‐incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli (E. coli) and methicillin‐resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens. The previously uncultured bacterium presents a viable strategy for the discovery of novel antimicrobial peptides. The antimicrobial peptide SR25 operates through a dual mechanism, targeting both the bacterial cell membrane and succinate:quinone oxidoreductase. It exhibits outstanding antibacterial efficacy and promotes the recovery of infected diabetes wounds.
The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections with Gram‐negative pathogens. Here, an antimicrobial peptide (AMP) SR25 is characterized, which effectively kills both Gram‐negative and Gram‐positive bacteria through a unique dual‐targeting mechanism without detectable resistance. Meanwhile, an SR25‐functionalized hydrogel is developed for the efficient treatment of infected diabetic wounds. SR25 is obtained through genome mining from an uncultured bovine enteric actinomycete named Nonomuraea Jilinensis sp. nov. Investigations reveal that SR25 has two independent cellular targets, disrupting bacterial membrane integrity and restraining the activity of succinate:quinone oxidoreductase (SQR). In a diabetic mice wound infection model, the SR25‐incorporated hydrogel exhibits high efficacy against mixed infections of Escherichia coli ( E. coli ) and methicillin‐resistant Staphylococcus aureus (MRSA), accelerating wound healing. Overall, these findings demonstrate the therapeutic potential of SR25 and highlight the value of mining drugs with multiple mechanisms from uncultured animal commensals for combating challenging bacterial pathogens.
Author Yin, Qi
Chen, Wei
Yang, Yong‐Jun
Luo, Xue‐Yue
Zhang, Xiao‐Mei
Liu, Zhen‐Zhen
Zhang, Jian‐Gang
Hu, Chun‐Mei
Zhou, Cheng‐Kai
AuthorAffiliation 1 Department of Preventive Veterinary Medicine College of Veterinary Medicine Jilin University Changchun Jilin 130062 P. R. China
AuthorAffiliation_xml – name: 1 Department of Preventive Veterinary Medicine College of Veterinary Medicine Jilin University Changchun Jilin 130062 P. R. China
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  surname: Luo
  fullname: Luo, Xue‐Yue
  organization: Jilin University
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  givenname: Chun‐Mei
  surname: Hu
  fullname: Hu, Chun‐Mei
  organization: Jilin University
– sequence: 3
  givenname: Qi
  surname: Yin
  fullname: Yin, Qi
  organization: Jilin University
– sequence: 4
  givenname: Xiao‐Mei
  surname: Zhang
  fullname: Zhang, Xiao‐Mei
  organization: Jilin University
– sequence: 5
  givenname: Zhen‐Zhen
  surname: Liu
  fullname: Liu, Zhen‐Zhen
  organization: Jilin University
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  surname: Zhou
  fullname: Zhou, Cheng‐Kai
  organization: Jilin University
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  surname: Chen
  fullname: Chen, Wei
  email: youngjune@jlu.edu.cn
  organization: Jilin University
– sequence: 9
  givenname: Yong‐Jun
  orcidid: 0000-0002-5294-9790
  surname: Yang
  fullname: Yang, Yong‐Jun
  email: chw_cc@jlu.edu.cn
  organization: Jilin University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38874469$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1039/D0CS01026J
10.1021/acsami.9b22595
10.1099/ijs.0.059774-0
10.1016/j.cell.2020.02.056
10.1002/adhm.202100877
10.1016/j.bioactmat.2022.01.009
10.1002/advs.202305078
10.1038/s41467-023-36994-z
10.1093/nar/gkab225
10.1186/s40779-021-00343-2
10.1016/j.actbio.2022.04.025
10.1021/acs.jafc.2c01458
10.1016/j.cbi.2020.109305
10.1186/s12929-022-00874-3
10.1073/pnas.0237315100
10.1038/nature12959
10.1093/molbev/msab120
10.1002/jcc.20291
10.1007/978-0-387-46312-4
10.1093/bioinformatics/btu097
10.1038/415389a
10.1021/acsnano.9b07836
10.15252/emmm.202115409
10.1016/j.lfs.2020.118381
10.1093/nar/gkv1051
10.1038/cdd.2010.93
10.1039/C6NP00025H
10.1038/nrd3591
10.1038/s41587-022-01226-0
10.1002/mabi.202200514
10.1093/nar/gkad344
10.1016/j.ejmech.2015.03.060
10.1016/j.drup.2016.04.002
10.1038/nrd3975
10.3390/gels9040265
10.1016/j.ijfoodmicro.2022.109953
10.1016/j.apsb.2019.05.002
10.1021/acs.jafc.6b00325
10.1186/s12864-022-08623-4
10.1093/nar/gkv1278
10.1002/advs.202305918
10.1038/s41522-022-00320-0
10.1002/ps.6762
10.1016/j.actbio.2021.01.046
10.1021/acsami.9b09824
10.1073/pnas.1612277113
10.1371/journal.ppat.1005098
10.1038/s41573-020-00114-z
10.1186/s40779-020-00249-5
10.1016/j.jconrel.2014.08.016
10.1016/j.gpb.2018.01.002
10.1016/j.cell.2023.07.038
10.1099/ijsem.0.002516
10.1016/j.apsb.2023.06.003
10.3389/fcimb.2021.809542
10.1099/ijs.0.65054-0
10.1099/ijs.0.056994-0
10.1002/advs.202300472
10.1126/science.7529940
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Issue 30
Keywords membrane disrupting
diabetic wound
hydrogel
succinate:quinone reductase
antimicrobial peptides
uncultured bacteria
Language English
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This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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References 2021; 20
2023; 186
2021; 124
2022; 70
2019; 11
2018 2014; 68 64
2019; 13
2023; 9
2022; 23
2020; 12
2005; 26
2013 2014; 12 506
2014; 64
2016; 33
2023 2020; 23 261
2022 2022; 383 29
2020; 7
2021; 38
2011 2021; 11 50
2022; 78
2016; 113
2020; 332
2016; 44
2023; 10
2021; 8
2023; 51
2021; 49
2019; 9
2023; 13
2023; 14
2023; 11
2020; 181
2002; 415
2006
2014; 194
2024; 11
2021; 1
2015 2021; 11 10
2022 2022 2022; 146 8 40
2007; 57
2003 2011; 100 18
2021; 11
2016 2015; 64 95
2022; 14
1995; 267
2014; 30
2016; 26
2018; 16
2022; 17
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References_xml – volume: 13
  year: 2019
  publication-title: ACS Nano.
– volume: 9
  start-page: 265
  year: 2023
  publication-title: Gels.
– volume: 49
  start-page: W216
  year: 2021
  publication-title: Nucleic Acids Res.
– volume: 100 18
  start-page: 473 338
  year: 2003 2011
  publication-title: Proc. Natl. Acad. Sci. USA. Cell Death Differ.
– volume: 23
  start-page: 380
  year: 2022
  publication-title: BMC Genomics.
– volume: 44
  year: 2016
  publication-title: Nucleic Acids Res.
– volume: 181
  start-page: 29
  year: 2020
  publication-title: Cell.
– volume: 13
  start-page: 3678
  year: 2023
  publication-title: Acta Pharm. Sin. B.
– volume: 26
  start-page: 1701
  year: 2005
  publication-title: J. Comput. Chem.
– volume: 124
  start-page: 205
  year: 2021
  publication-title: Acta Biomater.
– volume: 8
  start-page: 48
  year: 2021
  publication-title: Mil. Med. Res.
– volume: 70
  start-page: 5570
  year: 2022
  publication-title: J. Agric. Food Chem.
– volume: 11 50
  start-page: 37 4932
  year: 2011 2021
  publication-title: Nat Rev. Drug Discov. Chem. Soc. Rev.
– volume: 332
  year: 2020
  publication-title: Chem. Biol. Interact.
– volume: 11
  year: 2021
  publication-title: Front Cell Infect. Microbiol.
– volume: 26
  start-page: 43
  year: 2016
  publication-title: Drug Resist. Updat.
– volume: 383 29
  start-page: 89
  year: 2022 2022
  publication-title: Int. J. Food Microbiol. J. Biomed. Sci.
– volume: 14
  year: 2022
  publication-title: EMBO Mol. Med.
– volume: 23 261
  year: 2023 2020
  publication-title: Macromol. Biosci. Life Sci.
– volume: 194
  start-page: 138
  year: 2014
  publication-title: J. Control Release.
– volume: 267
  start-page: 383
  year: 1995
  publication-title: Science.
– volume: 113
  year: 2016
  publication-title: Proc. Natl. Acad. Sci. USA.
– volume: 146 8 40
  start-page: 131 58 921
  year: 2022 2022 2022
  publication-title: Acta. Biomater. NPJ Biofilms Microbiomes. Nat. Biotechnol.
– volume: 64 95
  start-page: 4830 424
  year: 2016 2015
  publication-title: J. Agric. Food Chem. Eur. J. Med. Chem.
– volume: 12
  year: 2020
  publication-title: ACS Appl. Mater. Interfaces.
– volume: 78
  start-page: 1448
  year: 2022
  publication-title: Pest Manag. Sci.
– volume: 16
  start-page: 405
  year: 2018
  publication-title: Genomics Proteomics Bioinformatics.
– volume: 10
  year: 2023
  publication-title: Adv. Sci. (Weinh).
– volume: 11
  year: 2023
  publication-title: Adv. Sci. (Weinh).
– volume: 1
  year: 2021
  publication-title: Cell Rep. Methods.
– volume: 20
  start-page: 200
  year: 2021
  publication-title: Nat. Rev. Drug Discov.
– volume: 12 506
  start-page: 371 58
  year: 2013 2014
  publication-title: Nat. Rev. Drug Discov. Nature.
– volume: 51
  start-page: W46
  year: 2023
  publication-title: Nucleic Acids Res.
– volume: 68 64
  start-page: 461 352
  year: 2018 2014
  publication-title: Int. J. Syst. Evol. Microbiol. Int. J. Syst. Evol. Microbiol.
– volume: 186
  start-page: 4059
  year: 2023
  publication-title: Cell.
– volume: 57
  start-page: 1504
  year: 2007
  publication-title: Int. J. Syst. Evol. Microbiol.
– volume: 17
  start-page: 471
  year: 2022
  publication-title: Bioact. Mater.
– volume: 7
  start-page: 20
  year: 2020
  publication-title: Mil. Med. Res.
– volume: 14
  start-page: 1453
  year: 2023
  publication-title: Nat. Commun.
– volume: 11 10
  year: 2015 2021
  publication-title: PLoS Pathog. Adv. Healthcare Mater.
– volume: 11
  year: 2024
  publication-title: Adv. Sci. (Weinh).
– volume: 64
  start-page: 346
  year: 2014
  publication-title: Int. J. Syst. Evol. Microbiol.
– volume: 9
  start-page: 1174
  year: 2019
  publication-title: Acta Pharm. Sin. B.
– year: 2006
– volume: 11
  year: 2019
  publication-title: ACS Appl. Mater. Interfaces.
– volume: 33
  start-page: 988
  year: 2016
  publication-title: Nat. Prod. Rep.
– volume: 38
  start-page: 3022
  year: 2021
  publication-title: Mol. Biol. Evol.
– volume: 415
  start-page: 389
  year: 2002
  publication-title: Nature.
– volume: 30
  start-page: 1771
  year: 2014
  publication-title: Bioinformatics.
– ident: e_1_2_8_5_2
  doi: 10.1039/D0CS01026J
– ident: e_1_2_8_50_1
  doi: 10.1021/acsami.9b22595
– ident: e_1_2_8_10_1
  doi: 10.1099/ijs.0.059774-0
– ident: e_1_2_8_16_1
  doi: 10.1016/j.cell.2020.02.056
– ident: e_1_2_8_1_2
  doi: 10.1002/adhm.202100877
– volume: 1
  year: 2021
  ident: e_1_2_8_40_1
  publication-title: Cell Rep. Methods.
– ident: e_1_2_8_49_1
  doi: 10.1016/j.bioactmat.2022.01.009
– ident: e_1_2_8_9_1
  doi: 10.1002/advs.202305078
– ident: e_1_2_8_38_1
  doi: 10.1038/s41467-023-36994-z
– ident: e_1_2_8_39_1
  doi: 10.1093/nar/gkab225
– ident: e_1_2_8_23_1
  doi: 10.1186/s40779-021-00343-2
– ident: e_1_2_8_8_1
  doi: 10.1016/j.actbio.2022.04.025
– ident: e_1_2_8_32_1
  doi: 10.1021/acs.jafc.2c01458
– ident: e_1_2_8_41_1
  doi: 10.1016/j.cbi.2020.109305
– ident: e_1_2_8_13_2
  doi: 10.1186/s12929-022-00874-3
– ident: e_1_2_8_14_1
  doi: 10.1073/pnas.0237315100
– ident: e_1_2_8_17_2
  doi: 10.1038/nature12959
– ident: e_1_2_8_33_1
  doi: 10.1093/molbev/msab120
– ident: e_1_2_8_47_1
  doi: 10.1002/jcc.20291
– ident: e_1_2_8_48_1
  doi: 10.1007/978-0-387-46312-4
– ident: e_1_2_8_46_1
  doi: 10.1093/bioinformatics/btu097
– ident: e_1_2_8_6_1
  doi: 10.1038/415389a
– ident: e_1_2_8_44_1
  doi: 10.1021/acsnano.9b07836
– ident: e_1_2_8_22_1
  doi: 10.15252/emmm.202115409
– ident: e_1_2_8_27_2
  doi: 10.1016/j.lfs.2020.118381
– ident: e_1_2_8_37_1
  doi: 10.1093/nar/gkv1051
– ident: e_1_2_8_14_2
  doi: 10.1038/cdd.2010.93
– ident: e_1_2_8_20_1
  doi: 10.1039/C6NP00025H
– ident: e_1_2_8_5_1
  doi: 10.1038/nrd3591
– ident: e_1_2_8_8_3
  doi: 10.1038/s41587-022-01226-0
– ident: e_1_2_8_27_1
  doi: 10.1002/mabi.202200514
– ident: e_1_2_8_35_1
  doi: 10.1093/nar/gkad344
– ident: e_1_2_8_24_2
  doi: 10.1016/j.ejmech.2015.03.060
– ident: e_1_2_8_7_1
  doi: 10.1016/j.drup.2016.04.002
– ident: e_1_2_8_17_1
  doi: 10.1038/nrd3975
– ident: e_1_2_8_28_1
  doi: 10.3390/gels9040265
– ident: e_1_2_8_13_1
  doi: 10.1016/j.ijfoodmicro.2022.109953
– ident: e_1_2_8_42_1
  doi: 10.1016/j.apsb.2019.05.002
– ident: e_1_2_8_24_1
  doi: 10.1021/acs.jafc.6b00325
– ident: e_1_2_8_34_1
  doi: 10.1186/s12864-022-08623-4
– ident: e_1_2_8_36_1
  doi: 10.1093/nar/gkv1278
– ident: e_1_2_8_2_1
  doi: 10.1002/advs.202305918
– ident: e_1_2_8_8_2
  doi: 10.1038/s41522-022-00320-0
– ident: e_1_2_8_25_1
  doi: 10.1002/ps.6762
– ident: e_1_2_8_26_1
  doi: 10.1016/j.actbio.2021.01.046
– ident: e_1_2_8_3_1
  doi: 10.1021/acsami.9b09824
– ident: e_1_2_8_29_1
  doi: 10.1073/pnas.1612277113
– ident: e_1_2_8_1_1
  doi: 10.1371/journal.ppat.1005098
– ident: e_1_2_8_19_1
  doi: 10.1038/s41573-020-00114-z
– ident: e_1_2_8_30_1
  doi: 10.1186/s40779-020-00249-5
– ident: e_1_2_8_31_1
  doi: 10.1016/j.jconrel.2014.08.016
– ident: e_1_2_8_21_1
  doi: 10.1016/j.gpb.2018.01.002
– ident: e_1_2_8_18_1
  doi: 10.1016/j.cell.2023.07.038
– ident: e_1_2_8_12_1
  doi: 10.1099/ijsem.0.002516
– ident: e_1_2_8_45_1
  doi: 10.1016/j.apsb.2023.06.003
– ident: e_1_2_8_43_1
  doi: 10.3389/fcimb.2021.809542
– ident: e_1_2_8_11_1
  doi: 10.1099/ijs.0.65054-0
– ident: e_1_2_8_12_2
  doi: 10.1099/ijs.0.056994-0
– ident: e_1_2_8_4_1
  doi: 10.1002/advs.202300472
– ident: e_1_2_8_15_1
  doi: 10.1126/science.7529940
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Snippet The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of infections...
Abstract The rise of antibiotic resistance poses a significant public health crisis, particularly due to limited antimicrobial options for the treatment of...
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SubjectTerms Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobial agents
antimicrobial peptides
Antimicrobial Peptides - pharmacology
Bacteria
Bacterial infections
Biocompatibility
Biofilms
Dairy cattle
Diabetes
Diabetes Mellitus, Experimental - drug therapy
diabetic wound
Disease Models, Animal
Drug resistance
E coli
Escherichia coli - drug effects
Genomes
hydrogel
Hydrogels
Listeria
membrane disrupting
Methicillin-Resistant Staphylococcus aureus - drug effects
Mice
Microbial Sensitivity Tests
Natural products
Peptides
Physiology
Salmonella
Staphylococcus infections
succinate:quinone reductase
uncultured bacteria
Wound Healing - drug effects
Wound Infection - drug therapy
Wound Infection - microbiology
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Title Dual‐Mechanism Peptide SR25 has Broad Antimicrobial Activity and Potential Application for Healing Bacteria‐infected Diabetic Wounds
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadvs.202401793
https://www.ncbi.nlm.nih.gov/pubmed/38874469
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