Understanding the pathogenesis of Alzheimer's disease: will RNA-Seq realize the promise of transcriptomics

• Published in: Journal of neurochemistry Vol. 116; no. 6; pp. 937 - 946
• Main Authors: Sutherland, Greg T, Janitz, Michal, Kril, Jillian J
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2011; Wiley-Blackwell
• Subjects: Adult and adolescent clinical studies; Alzheimer Disease - epidemiology; Alzheimer Disease - etiology; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Biological and medical sciences; Brain; Brain - metabolism; Brain - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Gene Expression Profiling; Humans; Kinesin - genetics; Medical sciences; Neurochemistry; Neurodegeneration; Neurology; Oligonucleotide Array Sequence Analysis - methods; Organic mental disorders. Neuropsychology; Pathogenesis; postmortem brain tissue; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Ribonucleic acid; RNA; RNA - analysis; RNA‐Seq; Sequence Analysis - methods; transcriptomic analysis; Human; Nervous system diseases; Prevalence; Methodology; Alzheimer disease; Pathogenesis; Central nervous system; Postmortem; Dynamic method; Encephalon; Cerebral disorder; Quantum; Treatment; Cell death; RNA-Seq; Central nervous system disease; postmortem brain tissue; transcriptomic analysis; Degenerative disease; Models; Alzheimer's disease; Signal detection

J. Neurochem. (2011) 116, 937-946. ABSTRACT: The prevalence of Alzheimer's disease (AD) is increasing rapidly in the western world and is poised to have a significant economic and societal impact. Current treatments do not alter the underlying disease processes meaning new treatments are requir...