Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: Data from the randomized, double-blind, COMBO-DN study

• Published in: Pain (Amsterdam) Vol. 155; no. 10; pp. 2171 - 2179
• Main Authors: Bouhassira, Didier, Wilhelm, Stefan, Schacht, Alexander, Perrot, Serge, Kosek, Eva, Cruccu, Giorgio, Freynhagen, Rainer, Tesfaye, Solomon, Lledó, Alberto, Choy, Ernest, Marchettini, Paolo, Micó, Juan Antonio, Spaeth, Michael, Skljarevski, Vladimir, Tölle, Thomas
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.10.2014; International Association for the Study of Pain; Elsevier
• Subjects: Aged; Aged, 80 and over; Analgesics - therapeutic use; Biological and medical sciences; Diabetes. Impaired glucose tolerance; Diabetic Neuropathies - complications; Diabetic Neuropathies - drug therapy; Diabetic neuropathy; Double-Blind Method; Duloxetine; Duloxetine Hydrochloride - therapeutic use; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; Male; Medical sciences; Middle Aged; Nervous system involvement in other diseases. Miscellaneous; Neuralgia - complications; Neuralgia - diagnosis; Neurology; Neuropathic Pain Symptom Inventory; Pregabalin; Pregabalin - therapeutic use; Sensory symptoms; Severity of Illness Index; Stratified treatment; Treatment Outcome; Stratified treatment; Diabetic neuropathy; Sensory symptoms; Neuropathic Pain Symptom Inventory; Duloxetine; Pregabalin; Endocrinopathy; Nervous system diseases; Questionnaire; Diabetes mellitus; Psychometrics; Neuropathy; Neuropathic pain; Symptomatology; Treatment; Double blind study; Predictive factor

Duloxetine and pregabalin have different effects on neuropathic pain components. This might explain differential responses to these drugs when given either alone or in combination. Sensory profiles are heterogeneous in neuropathic pain disorders, and subgroups of patients respond differently to trea...