Digitally Tunable Microfluidic Bioprinting of Multilayered Cannular Tissues

• Published in: Advanced materials (Weinheim) Vol. 30; no. 43; pp. e1706913 - n/a
• Main Authors: Pi, Qingmeng, Maharjan, Sushila, Yan, Xiang, Liu, Xiao, Singh, Bijay, Genderen, Anne Metje, Robledo‐Padilla, Felipe, Parra‐Saldivar, Roberto, Hu, Ning, Jia, Weitao, Xu, Changliang, Kang, Jian, Hassan, Shabir, Cheng, Haibo, Hou, Xu, Khademhosseini, Ali, Zhang, Yu Shrike
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2018
• Subjects: Alginates; Biocompatible Materials; Bioengineering; bioinks; Bioprinting - instrumentation; Bioprinting - methods; Bladder; Blood Vessel Prosthesis; Blood vessels; cannular tissues; Cell Survival; Circumferences; coaxial extrusion systems; Colon; Endothelial cells; Extrusion; Gelatin; Human Umbilical Vein Endothelial Cells; Humans; Hydrogels; Materials science; Materials Testing; microfluidic bioprinting; Microfluidics - instrumentation; Muscles; Myocytes, Smooth Muscle; Nutrients; Organs; perfusion; Polyethylene glycol; Printing, Three-Dimensional - instrumentation; Smooth muscle; Three dimensional printing; Tissue engineering; Tissue Scaffolds; Trachea; Urinary Bladder; Urothelium; Vascular tissue; Well construction; bioinks; cannular tissues; microfluidic bioprinting; perfusion; coaxial extrusion systems

Despite advances in the bioprinting technology, biofabrication of circumferentially multilayered tubular tissues or organs with cellular heterogeneity, such as blood vessels, trachea, intestine, colon, ureter, and urethra, remains a challenge. Herein, a promising multichannel coaxial extrusion syste...