Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors

• Published in: Advanced science Vol. 11; no. 41; pp. e2403389 - n/a
• Main Authors: Mo, Jia‐Wen, Kong, Peng‐Li, Ding, Li, Fan, Jun, Ren, Jing, Lu, Cheng‐Lin, Guo, Fang, Chen, Liang‐Yu, Mo, Ran, Zhong, Qiu‐Ling, Wen, You‐Lu, Gu, Ting‐Ting, Wang, Qian‐Wen, Li, Shu‐Ji, Guo, Ting, Gao, Tian‐Ming, Cao, Xiong
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.11.2024; John Wiley and Sons Inc; Wiley
• Subjects: Animals; astrocytes; Astrocytes - metabolism; ATP; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; Behavior, Animal; Brain; Depression - genetics; Depression - metabolism; depressive‐like behaviors; Disease Models, Animal; Humans; lysosomes; Lysosomes - metabolism; Male; Mental depression; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy; Morphology; mucolipin TRP channel 1; Neurons; Prefrontal Cortex - metabolism; Proteins; Quantitative analysis; Signal Transduction - genetics; Stress; transcription factor EB; Transient Receptor Potential Channels - genetics; Transient Receptor Potential Channels - metabolism; transcription factor EB; lysosomes; astrocytes; depressive‐like behaviors; ATP; mucolipin TRP channel 1

Lysosomes are important cellular structures for human health as centers for recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is found that lysosomal morphology in astrocytes is altered in th...