TRAIL、NF-κB和Caspase-3在大肠癌中的表达及意义
R735.3+4; 目的 研究TRAIL、NF-κB和Caspase-3在大肠癌中的表达及意义,探讨NF-κB和Caspase-3的表达对TRAIL抗癌作用的影响.方法 采用免疫组化SP法检测42例大肠癌及其癌旁5cm组织、25例正常大肠粘膜组织中TRAIL、NF-κB和Caspase-3蛋白的表达水平.结果 TRAIL和 Caspase-3在大肠癌、癌旁组织及正常大肠粘膜组织中的表达呈递增趋势,而NF-κB的表达则与之相反(P＜0.05);TRAIL和Caspase-3在中、低分化癌中的表达明显低于高分化癌中的表达,而NF-κB的表达则与之相反(P＜0.05);TRAIL与NF-κB和Cas...
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| Published in | 肿瘤防治研究 Vol. 34; no. 4; pp. 256 - 插1 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
石家庄市第一医院普外二科
2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-8578 |
| DOI | 10.3971/j.issn.1000-8578.2007.04.007 |
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| Abstract | R735.3+4; 目的 研究TRAIL、NF-κB和Caspase-3在大肠癌中的表达及意义,探讨NF-κB和Caspase-3的表达对TRAIL抗癌作用的影响.方法 采用免疫组化SP法检测42例大肠癌及其癌旁5cm组织、25例正常大肠粘膜组织中TRAIL、NF-κB和Caspase-3蛋白的表达水平.结果 TRAIL和 Caspase-3在大肠癌、癌旁组织及正常大肠粘膜组织中的表达呈递增趋势,而NF-κB的表达则与之相反(P＜0.05);TRAIL和Caspase-3在中、低分化癌中的表达明显低于高分化癌中的表达,而NF-κB的表达则与之相反(P＜0.05);TRAIL与NF-κB和Caspase-3在大肠癌中的表达均显著相关(P＜0.05).结论 TRAIL、NF-κB和Caspase-3可能与大肠癌的发生、发展密切相关;抑制NF-κB表达及促进Caspase-3的表达,有可能提高肿瘤细胞对TRAIL的敏感性. |
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| AbstractList | R735.3+4; 目的 研究TRAIL、NF-κB和Caspase-3在大肠癌中的表达及意义,探讨NF-κB和Caspase-3的表达对TRAIL抗癌作用的影响.方法 采用免疫组化SP法检测42例大肠癌及其癌旁5cm组织、25例正常大肠粘膜组织中TRAIL、NF-κB和Caspase-3蛋白的表达水平.结果 TRAIL和 Caspase-3在大肠癌、癌旁组织及正常大肠粘膜组织中的表达呈递增趋势,而NF-κB的表达则与之相反(P＜0.05);TRAIL和Caspase-3在中、低分化癌中的表达明显低于高分化癌中的表达,而NF-κB的表达则与之相反(P＜0.05);TRAIL与NF-κB和Caspase-3在大肠癌中的表达均显著相关(P＜0.05).结论 TRAIL、NF-κB和Caspase-3可能与大肠癌的发生、发展密切相关;抑制NF-κB表达及促进Caspase-3的表达,有可能提高肿瘤细胞对TRAIL的敏感性. |
| Author | 闫庆辉 张国建 刘津 薛平 王凤安 罗玉贤 蔡建辉 |
| AuthorAffiliation | 石家庄市第一医院普外二科 |
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| Author_FL | ZHANG Guo-jian WANG Feng-an LUO Yu-xian XUE Ping YAN Qing-hui CAI Jian-hui LIU Jin |
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| Keywords | 结直肠肿瘤 NF-κB TRAIL 免疫组织化学 Caspase-3 |
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| Snippet | R735.3+4; 目的 研究TRAIL、NF-κB和Caspase-3在大肠癌中的表达及意义,探讨NF-κB和Caspase-3的表达对TRAIL抗癌作用的影响.方法 采用免疫组化SP法检测42例大肠癌及其癌旁5cm组织、25例正常大肠粘膜组织中TRAIL、NF-κB和Caspase-3蛋白的表达水平.结果... |
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| Title | TRAIL、NF-κB和Caspase-3在大肠癌中的表达及意义 |
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