The Crc Global Regulator Inhibits the Pseudomonas putida pWW0 Toluene/Xylene Assimilation Pathway by Repressing the Translation of Regulatory and Structural Genes

• Published in: The Journal of biological chemistry Vol. 285; no. 32; pp. 24412 - 24419
• Main Authors: Moreno, Renata, Fonseca, Pilar, Rojo, Fernando
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.08.2010; American Society for Biochemistry and Molecular Biology
• Subjects: Bacterial Metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - metabolism; Base Sequence; Carbon sources; Catabolite Repression; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Gene Regulation; Global Regulation; Hydrocarbons; Metabolic Regulation; Microbiology; Models, Biological; Models, Genetic; Molecular Sequence Data; Oligonucleotides - genetics; Plasmids; Promoter Regions, Genetic; Pseudomonas putida; Pseudomonas putida - metabolism; Repressor Proteins - chemistry; Repressor Proteins - metabolism; Repressors; RNA, Messenger - metabolism; RNA-binding Protein; RNA-Binding Proteins - metabolism; Toluene; Toluene - chemistry; Transcription factors; Transcription, Genetic; Translation; Translation initiation; Translation Regulation; Xylene; Xylenes - chemistry; Catabolite Repression; Gene Expression; Translation Regulation; Bacterial Metabolism; Metabolic Regulation; Global Regulation; RNA-binding Protein

In Pseudomonas putida, the expression of the pWW0 plasmid genes for the toluene/xylene assimilation pathway (the TOL pathway) is subject to complex regulation in response to environmental and physiological signals. This includes strong inhibition via catabolite repression, elicited by the carbon sou...