Nose-to-brain transport of aerosolised quantum dots following acute exposure
Abstract Nanoparticles are of wide interest due to their potential use for diverse commercial applications. Quantum dots (QDs) are semiconductor nanocrystals possessing unique optical and electrical properties. Although QDs are commonly made of cadmium, a metal known to have neurological effects, po...
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Published in | Nanotoxicology Vol. 8; no. 8; pp. 885 - 893 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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England
Informa UK, Ltd
01.12.2014
Taylor & Francis |
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Abstract | Abstract
Nanoparticles are of wide interest due to their potential use for diverse commercial applications. Quantum dots (QDs) are semiconductor nanocrystals possessing unique optical and electrical properties. Although QDs are commonly made of cadmium, a metal known to have neurological effects, potential transport of QDs directly to the brain has not been assessed. This study evaluated whether QDs (CdSe/ZnS nanocrystals) could be transported from the olfactory tract to the brain via inhalation. Adult C57BL/6 mice were exposed to an aerosol of QDs for 1 h via nasal inhalation, and nanoparticles were detected 3 h post-exposure within the olfactory tract and olfactory bulb by a wide range of techniques, including visualisation via fluorescent and transmission electron microscopy. We conclude that, following short-term inhalation of solid QD nanoparticles, there is rapid olfactory uptake and axonal transport to the brain/olfactory bulb with observed activation of microglial cells, indicating a pro-inflammatory response. To our knowledge, this is the first study to clearly demonstrate that QDs can be rapidly transported from the nose to the brain by olfactory uptake via axonal transport following inhalation. |
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AbstractList | Nanoparticles are of wide interest due to their potential use for diverse commercial applications. Quantum dots (QDs) are semiconductor nanocrystals possessing unique optical and electrical properties. Although QDs are commonly made of cadmium, a metal known to have neurological effects, potential transport of QDs directly to the brain has not been assessed. This study evaluated whether QDs (CdSe/ZnS nanocrystals) could be transported from the olfactory tract to the brain via inhalation. Adult C57BL/6 mice were exposed to an aerosol of QDs for 1 h via nasal inhalation, and nanoparticles were detected 3 h post-exposure within the olfactory tract and olfactory bulb by a wide range of techniques, including visualisation via fluorescent and transmission electron microscopy. We conclude that, following short-term inhalation of solid QD nanoparticles, there is rapid olfactory uptake and axonal transport to the brain/olfactory bulb with observed activation of microglial cells, indicating a pro-inflammatory response. To our knowledge, this is the first study to clearly demonstrate that QDs can be rapidly transported from the nose to the brain by olfactory uptake via axonal transport following inhalation. Abstract Nanoparticles are of wide interest due to their potential use for diverse commercial applications. Quantum dots (QDs) are semiconductor nanocrystals possessing unique optical and electrical properties. Although QDs are commonly made of cadmium, a metal known to have neurological effects, potential transport of QDs directly to the brain has not been assessed. This study evaluated whether QDs (CdSe/ZnS nanocrystals) could be transported from the olfactory tract to the brain via inhalation. Adult C57BL/6 mice were exposed to an aerosol of QDs for 1 h via nasal inhalation, and nanoparticles were detected 3 h post-exposure within the olfactory tract and olfactory bulb by a wide range of techniques, including visualisation via fluorescent and transmission electron microscopy. We conclude that, following short-term inhalation of solid QD nanoparticles, there is rapid olfactory uptake and axonal transport to the brain/olfactory bulb with observed activation of microglial cells, indicating a pro-inflammatory response. To our knowledge, this is the first study to clearly demonstrate that QDs can be rapidly transported from the nose to the brain by olfactory uptake via axonal transport following inhalation. |
Author | Pinkerton, Kent E. Brandenberger, Christina Patchin, Esther S. Hopkins, Laurie E. Chiu, Po-Lin Smiley-Jewell, Suzette |
Author_xml | – sequence: 1 givenname: Laurie E. surname: Hopkins fullname: Hopkins, Laurie E. email: kepinkerton@ucdavis.edu, kepinkerton@ucdavis.edu organization: Center for Health and the Environment, University of California – sequence: 2 givenname: Esther S. surname: Patchin fullname: Patchin, Esther S. email: kepinkerton@ucdavis.edu, kepinkerton@ucdavis.edu organization: Center for Health and the Environment, University of California – sequence: 3 givenname: Po-Lin surname: Chiu fullname: Chiu, Po-Lin email: kepinkerton@ucdavis.edu, kepinkerton@ucdavis.edu organization: Molecular and Cellular Biology – sequence: 4 givenname: Christina surname: Brandenberger fullname: Brandenberger, Christina email: kepinkerton@ucdavis.edu, kepinkerton@ucdavis.edu organization: Institute of Anatomy, University of Bern – sequence: 5 givenname: Suzette surname: Smiley-Jewell fullname: Smiley-Jewell, Suzette email: kepinkerton@ucdavis.edu, kepinkerton@ucdavis.edu organization: Center for Health and the Environment, University of California – sequence: 6 givenname: Kent E. surname: Pinkerton fullname: Pinkerton, Kent E. email: kepinkerton@ucdavis.edu, kepinkerton@ucdavis.edu organization: Center for Health and the Environment, University of California |
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Nanoparticles are of wide interest due to their potential use for diverse commercial applications. Quantum dots (QDs) are semiconductor nanocrystals... Nanoparticles are of wide interest due to their potential use for diverse commercial applications. Quantum dots (QDs) are semiconductor nanocrystals possessing... |
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SubjectTerms | Administration, Inhalation Administration, Intranasal Aerosols Aerosols - administration & dosage Aerosols - pharmacokinetics Animals Brain Bulbs Inhalation Mice Mice, Inbred C57BL Microglia - chemistry Microglia - metabolism Nanocrystals Nanoparticles Nasal Cavity - chemistry Nasal Cavity - metabolism olfactory bulb Olfactory Bulb - chemistry Olfactory Bulb - metabolism olfactory epithelium Olfactory Mucosa - chemistry Olfactory Mucosa - metabolism Particle Size qdots Quantum Dots Semiconductors Transport |
Title | Nose-to-brain transport of aerosolised quantum dots following acute exposure |
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