Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis

• Published in: Journal of pediatric surgery Vol. 51; no. 1; pp. 13 - 17
• Main Authors: Grishin, Anatoly, Bowling, Jordan, Bell, Brandon, Wang, Jin, Ford, Henri R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2016
• Subjects: Bacteria; Biomarkers - metabolism; Enterocolitis, Necrotizing - etiology; Enterocolitis, Necrotizing - metabolism; Enterocolitis, Necrotizing - microbiology; Gastrointestinal Microbiome; Gut barrier; Humans; Infant, Newborn; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Necrotizing enterocolitis; Nitric oxide; Nitric Oxide - metabolism; Pediatrics; Permeability; Surgery; Necrotizing enterocolitis; Bacteria; Nitric oxide; Gut barrier

Abstract Necrotizing enterocolitis remains one of the most vexing problems in the neonatal intensive care unit. Risk factors for NEC include prematurity, formula feeding, and inappropriate microbial colonization of the GI tract. The pathogenesis of NEC is believed to involve weakening of the intesti...