Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation

• Published in: Placenta (Eastbourne) Vol. 36; no. 10; pp. 1078 - 1086
• Main Authors: Jones, Helen N, Olbrych, Stephanie K, Smith, Kathleen L, Cnota, James F, Habli, Mounira, Ramos-Gonzales, Osniel, Owens, Kathryn J, Hinton, Andrea C, Polzin, William J, Muglia, Louis J, Hinton, Robert B
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2015
• Subjects: Angiogenesis; Birth Weight; Congenital heart disease; Female; Fibrin - metabolism; Humans; Hypoplastic Left Heart Syndrome - metabolism; Hypoplastic Left Heart Syndrome - pathology; Internal Medicine; Leptin - metabolism; Obstetrics and Gynecology; Organ Size; Placenta - blood supply; Placenta - metabolism; Placenta - pathology; Placenta Growth Factor; Pregnancy; Pregnancy Proteins - metabolism; Receptors, Leptin - metabolism; Retrospective Studies; Vascular biology; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor Receptor-2 - metabolism; Angiogenesis; Congenital heart disease; Vascular biology

Abstract Introduction Hypoplastic left heart syndrome (HLHS) is a severe cardiovascular malformation (CVM) associated with fetal growth abnormalities. Genetic and environmental factors have been identified that contribute to pathogenesis, but the role of the placenta is unknown. The purpose of this...