Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012-2013

• Published in: Malaria journal Vol. 13; no. 1; p. 472
• Main Authors: Torrentino-Madamet, Marylin, Fall, Bécaye, Benoit, Nicolas, Camara, Cheikhou, Amalvict, Rémy, Fall, Mansour, Dionne, Pierre, Ba Fall, Kadidiatou, Nakoulima, Aminata, Diatta, Bakary, Diemé, Yaya, Ménard, Didier, Wade, Boubacar, Pradines, Bruno
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.12.2014; BioMed Central
• Subjects: Amino Acid Substitution; Analysis; Antimalarials; Antimalarials - pharmacology; Artemisinins; Artemisinins - pharmacology; Codon; DNA, Protozoan; DNA, Protozoan - chemistry; DNA, Protozoan - genetics; Drug Resistance; Genetic aspects; Genetic polymorphisms; Genetic research; Genotype; Health aspects; Human health and pathology; Humans; Infectious diseases; Lactones; Lactones - pharmacology; Life Sciences; Malaria; Malaria, Falciparum; Malaria, Falciparum - parasitology; Mutation, Missense; Plasmodium falciparum; Plasmodium falciparum - classification; Plasmodium falciparum - drug effects; Plasmodium falciparum - genetics; Plasmodium falciparum - isolation & purification; Polymerase Chain Reaction; Polymorphism, Genetic; Protozoan Proteins; Protozoan Proteins - genetics; Senegal; Sequence Analysis, DNA; Senegal; Southeast Asia; Asia; Senegal, Dakar; Africa; Resistance; artemisinin; Plasmodium falciparum; Malaria; Senegal; Anti-malarial drug; K13-propeller; Molecular marker

The emergence of Plasmodium falciparum resistance to artemisinin and its derivatives, manifested as delayed parasite clearance following the treatment, has developed in Southeast Asia. The spread of resistance to artemisinin from Asia to Africa may be catastrophic for malaria control and elimination...