Astrocyte–endothelial interactions at the blood–brain barrier

• Published in: Nature reviews. Neuroscience Vol. 7; no. 1; pp. 41 - 53
• Main Authors: Abbott, N. Joan, Rönnbäck, Lars, Hansson, Elisabeth
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2006; Nature Publishing Group
• Subjects: Animal Genetics and Genomics; Animals; aquaporin-4 messenger-rna; Astrocytes - physiology; Behavioral Sciences; Biological and medical sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Blood-Brain Barrier - cytology; Blood-Brain Barrier - physiology; Brain; calcium signal communication; Cell Communication - physiology; central-nervous-system; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Cerebrospinal fluid; Endothelial Cells - physiology; Endothelium; Enzymes; Fundamental and applied biological sciences. Psychology; General aspects. Models. Methods; glucose-transporter; human glioblastoma-multiforme; Humans; in-vitro; low-density-lipoprotein; Models, Biological; necrosis-factor-alpha; Neurobiology; Neurosciences; Neurovetenskaper; nitric-oxide synthase; p-glycoprotein expression; Peptides; Permeability; review-article; Tight Junctions - physiology; Vertebrates: nervous system and sense organs; Endothelial cell; Neuron; Organization; Neuroglia; Interaction; Central nervous system; Review; Astrocyte; Blood brain barrier; Encephalon; Endothelium

Key Points The blood–brain barrier (BBB), which is formed by the endothelial cells that line cerebral microvessels, has an important role in maintaining a precisely regulated microenvironment for reliable neuronal signalling. There is great interest in the association of brain microvessels, astrocyt...