Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferen...
Saved in:
| Published in | Brazilian journal of microbiology Vol. 46; no. 1; pp. 125 - 129 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Brazil
Springer Nature B.V
01.05.2015
Sociedade Brasileira de Microbiologia |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata , a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro , notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies. |
|---|---|
| AbstractList | In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata, a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro, notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies. In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata , a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro , notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies. |
| Author | Alves, Sydney Hartz Santurio, Janio Morais Denardi, Laura Bedin Loreto, Érico Silva Mario, Débora Alves Nunes |
| AuthorAffiliation | 2 Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil 1 Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil |
| AuthorAffiliation_xml | – name: 1 Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil – name: 2 Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil – name: Universidade Federal de Santa Maria |
| Author_xml | – sequence: 1 givenname: Laura Bedin surname: Denardi fullname: Denardi, Laura Bedin organization: Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil – sequence: 2 givenname: Débora Alves Nunes surname: Mario fullname: Mario, Débora Alves Nunes organization: Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil – sequence: 3 givenname: Érico Silva surname: Loreto fullname: Loreto, Érico Silva organization: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil – sequence: 4 givenname: Janio Morais surname: Santurio fullname: Santurio, Janio Morais organization: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil – sequence: 5 givenname: Sydney Hartz surname: Alves fullname: Alves, Sydney Hartz organization: Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26221097$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdUtuKFDEQDbLiXvQTlIAv-9Jr7p1-EWTwBgs-rD6HmnR6zJJOxiQtrD_hL29mZx1mhYIE6pxTVafqHJ3EFB1Crym5onIg7wqVtO8010woykgLIdgzdEZVrzshiDw5-p-i81JuCWGSCPYCnTLFGCVDf4b-3txFlze-VG-xmyZna8FpwhVsTsHPS8EQRwx_UnDtV_20xA0EbNO8TUscC_YRT2GxKT5gurIU67bVrx_w45NcdqUVaip41VJ-BLwJsM5QAfuSAlRXXqLnE4TiXj2-F-jHp4_fV1-662-fv64-XHdWDqp2vRzAOTFOVlALoDSRa8k0MAFArKVUEuCCW6oY1yPrBROCSk3VMFqlQfALdLXXLda7kMxtWnJsBc3Nzlez87WZKgkhtAWTjfB-T9gu69mN1sWaIZht9jPkO5PAm6eZ6H-aTfpthGy76VUTuHwUyOnX4ko1s29WhQDRpaUY2hPCuWhTNOjb_6CH9qgmnCiu5K4juUe1TZWS3XRohhKzu5GjWY5upPHeHE9yYP07Cn4PpZi6Qw |
| CitedBy_id | crossref_primary_10_1007_s11046_019_00419_7 crossref_primary_10_1371_journal_pone_0182653 crossref_primary_10_1093_mmy_myx088 crossref_primary_10_1093_mmy_myy035 crossref_primary_10_1007_s11046_018_0242_0 crossref_primary_10_1093_jac_dkad359 crossref_primary_10_3390_ph15040482 crossref_primary_10_1099_jmm_0_001161 crossref_primary_10_7717_peerj_4999 crossref_primary_10_2174_1568026619666191025152412 crossref_primary_10_1016_j_vetmic_2019_05_022 crossref_primary_10_3314_mmj_20_00014 crossref_primary_10_1021_acsmedchemlett_6b00355 crossref_primary_10_1080_09273948_2019_1643030 crossref_primary_10_1016_j_jgar_2020_02_010 crossref_primary_10_3389_fmicb_2020_02077 crossref_primary_10_1111_vde_12805 crossref_primary_10_1016_j_bjid_2016_08_008 crossref_primary_10_1093_mmy_myw101 crossref_primary_10_5604_01_3001_0016_2158 crossref_primary_10_1093_mmy_myad069 crossref_primary_10_1136_bcr_2021_242917 crossref_primary_10_1371_journal_pone_0161371 crossref_primary_10_3389_fmicb_2017_01759 crossref_primary_10_3389_fcimb_2022_864912 crossref_primary_10_1099_jmm_0_001354 |
| ContentType | Journal Article |
| Copyright | Copyright Sociedade Brasileira de Microbiologia 2015 This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License. |
| Copyright_xml | – notice: Copyright Sociedade Brasileira de Microbiologia 2015 – notice: This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QL 7U9 7X7 7XB 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA ATCPS AZQEC BBNVY BENPR BHPHI C1K CCPQU CLZPN DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M2P M7N M7P PATMY PQEST PQQKQ PQUKI PRINS PYCSY Q9U 7X8 5PM GPN |
| DOI | 10.1590/s1517-838246120120442 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Virology and AIDS Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College Latin America & Iberia Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Journals Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Environmental Science Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Environmental Science Collection ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) SciELO |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Environmental Science Collection ProQuest Health & Medical Complete ProQuest Medical Library Latin America & Iberian Database ProQuest One Academic UKI Edition Environmental Science Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1678-4405 |
| EndPage | 129 |
| ExternalDocumentID | S1517_83822015000100125 4114095421 10_1590_S1517_838246120120442 26221097 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Feature |
| GroupedDBID | 0R~ 0SF 23N 2WC 3V. 406 457 53G 5GY 5VS 6I. 6J9 7X7 7XC 88E 88I 8FE 8FH 8FI 8FJ AACDK AACTN AAEDW AAFTH AAHBH AAHNG AAJBT AALRI AASML AATNV AAUYE AAXUO ABAKF ABECU ABFTV ABJNI ABKCH ABMAC ABMQK ABTEG ABTKH ABTMW ABUWG ABXHO ACAOD ACDTI ACGFO ACGFS ACGOD ACHSB ACIPQ ACOKC ACPRK ACZOJ ADBBV ADFRT ADKNI ADTPH ADURQ ADVLN ADYFF AEFQL AEMSY AENEX AESKC AEXQZ AFBBN AFKRA AFQWF AFRAH AGDGC AGHFR AGMZJ AGQEE AHMBA AIGIU AILAN AITGF AITUG AJZVZ AKRWK ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMRAJ AMTXH AMXSW AMYLF AOIJS APOWU ATCPS AXYYD AZFZN AZQEC BAWUL BBNVY BCNDV BENPR BGNMA BHPHI BPHCQ BVXVI C1A CCPQU CGR CLZPN CS3 CSCUP CUY CVF DIK DPUIP DU5 DWQXO E3Z EBLON EBS ECM EIF EJD FDB FIGPU FNLPD FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IKXTQ IPNFZ IWAJR JZLTJ KOV KQ8 LK8 LLZTM M1P M2P M41 M4Y M7P M~E NCXOZ NPM NPVJJ NQJWS NU0 O9- OK1 P2P PATMY PQQKQ PROAC PSQYO PT4 PYCSY RIG RNS ROL RPM RSC RSV SCD SJYHP SNE SNPRN SOHCF SOJ SRMVM SSLCW SSZ TR2 UKHRP UOJIU UTJUX VEKWB VFIZW XSB ZMTXR AAYXX CITATION 7QL 7U9 7XB 8FK C1K H94 K9. M7N PQEST PQUKI PRINS Q9U 7X8 5PM GPN |
| ID | FETCH-LOGICAL-c596t-759aee4dfc41caa6805b528a24aa0cc1150a343c16238d274244158169dc68a43 |
| IEDL.DBID | RPM |
| ISSN | 1678-4405 1517-8382 |
| IngestDate | Fri Oct 18 20:39:44 EDT 2024 Tue Sep 17 21:17:28 EDT 2024 Fri Oct 25 04:41:46 EDT 2024 Thu Oct 10 17:41:25 EDT 2024 Thu Sep 12 16:45:07 EDT 2024 Sat Sep 28 08:02:03 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | azole resistance combination therapy Candida glabrata FK506 |
| Language | English |
| License | All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License CC BY-NC. This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License. http://creativecommons.org/licenses/by-nc/3.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c596t-759aee4dfc41caa6805b528a24aa0cc1150a343c16238d274244158169dc68a43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Associate Editor: Carlos Pelleschi Taborda |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512076/ |
| PMID | 26221097 |
| PQID | 1803063655 |
| PQPubID | 1536339 |
| PageCount | 5 |
| ParticipantIDs | scielo_journals_S1517_83822015000100125 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4512076 proquest_miscellaneous_1700334528 proquest_journals_1803063655 crossref_primary_10_1590_S1517_838246120120442 pubmed_primary_26221097 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-05-01 |
| PublicationDateYYYYMMDD | 2015-05-01 |
| PublicationDate_xml | – month: 05 year: 2015 text: 2015-05-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Brazil |
| PublicationPlace_xml | – name: Brazil – name: São Paulo |
| PublicationTitle | Brazilian journal of microbiology |
| PublicationTitleAlternate | Braz J Microbiol |
| PublicationYear | 2015 |
| Publisher | Springer Nature B.V Sociedade Brasileira de Microbiologia |
| Publisher_xml | – name: Springer Nature B.V – name: Sociedade Brasileira de Microbiologia |
| References | 22278842 - J Clin Microbiol. 2012 Apr;50(4):1199-203 15105118 - Antimicrob Agents Chemother. 2004 May;48(5):1664-9 11165110 - Int J Antimicrob Agents. 2001 Feb;17(2):81-91 11847103 - EMBO J. 2002 Feb 15;21(4):546-59 12751263 - Infect Dis Clin North Am. 2003 Mar;17(1):113-34, viii 12933882 - Infect Immun. 2003 Sep;71(9):5344-54 23027188 - Antimicrob Agents Chemother. 2012 Dec;56(12):6417-21 18056277 - Antimicrob Agents Chemother. 2008 Feb;52(2):409-17 11036397 - Mycoses. 2000 Sep;43(7-8):273-9 15653825 - Clin Microbiol Rev. 2005 Jan;18(1):163-94 12604527 - Antimicrob Agents Chemother. 2003 Mar;47(3):956-64 16113294 - Infect Immun. 2005 Sep;73(9):5767-74 19191635 - Clin Infect Dis. 2009 Mar 1;48(5):503-35 10995587 - Semin Immunol. 2000 Aug;12(4):405-15 22653819 - J Antimicrob Chemother. 2012 Sep;67(9):2268-73 14982754 - Antimicrob Agents Chemother. 2004 Mar;48(3):693-715 22514266 - J Antimicrob Chemother. 2012 Jul;67(7):1666-76 22762208 - Med Mycol. 2013 Jan;51(1):38-44 17223626 - Clin Microbiol Rev. 2007 Jan;20(1):133-63 23487382 - Clin Infect Dis. 2013 Jun;56(12):1724-32 18785850 - Infect Control Hosp Epidemiol. 2008 Sep;29(9):898-9 15893902 - Diagn Microbiol Infect Dis. 2005 Aug;52(4):285-93 23693017 - Braz J Infect Dis. 2013 May-Jun;17(3):283-312 2012; 50 2013; 17 2000; 12 2013; 56 2013; 51 2000; 43 2008; 29 2004; 48 2002; 21 2005; 73 2005; 52 2008 2003; 47 2003; 17 2001; 17 2008; 52 2003; 71 2007; 20 2012; 67 2012; 56 2005; 18 2009; 48 |
| References_xml | – volume: 52 start-page: 409 year: 2008 end-page: 417 article-title: In vitro interactions between tacrolimus and Azoles against Candida albicans determined by different methods publication-title: Antimicrob Agents Chemother – volume: 56 start-page: 6417 year: 2012 end-page: 6421 article-title: Two clinical isolates of Candida glabrataexhibiting reduced sensitivity to amphotericin B both harbor mutations in ERG2 publication-title: Antimicrob Agents Chemother – volume: 20 start-page: 133 year: 2007 end-page: 163 article-title: Epidemiology of invasive candidiasis: A persistent public health problem publication-title: Clin Microbiol Rev – volume: 12 start-page: 405 year: 2000 end-page: 415 article-title: The role of calcineurin in lymphocyte activation publication-title: Semin Immunol – volume: 17 start-page: 283 year: 2013 end-page: 312 article-title: Brazilian guidelines for the management of candidiasis – a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical publication-title: Braz J Infect Dis – year: 2008 publication-title: Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard. M27-A3 – volume: 29 start-page: 898 year: 2008 end-page: 899 article-title: Take control over your fluconazole prescriptions: The growing importance of Candida glabrata as an agent of candidemia in Brazil publication-title: Infect Control Hosp Epidemiol – volume: 71 start-page: 5344 year: 2003 end-page: 5354 article-title: Calcineurin is essential for virulence in Candida albicans publication-title: Infect Immun – volume: 17 start-page: 113 year: 2003 end-page: 134 article-title: Fungal infections in the recipients of solid organ transplantation publication-title: Infect Dis Clin North Am – volume: 67 start-page: 2268 year: 2012 end-page: 2273 article-title: Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: real-life data from a single-centre institutional retrospective observational study publication-title: J Antimicrob Chemother – volume: 48 start-page: 693 year: 2004 end-page: 715 article-title: Combination antifungal therapy publication-title: Antimicrob Agents Chemother – volume: 67 start-page: 1666 year: 2012 end-page: 1676 article-title: Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression publication-title: J Antimicrob Chemother – volume: 52 start-page: 175 year: 2005 end-page: 180 article-title: Sterol uptake in Candida glabrata: Rescue of sterol auxotrophic strains publication-title: Diagn Microbiol Infect Dis – volume: 51 start-page: 38 year: 2013 end-page: 44 article-title: Candida glabrata: an emerging pathogen in Brazilian tertiary care hospitals publication-title: Med Mycol – volume: 21 start-page: 546 year: 2002 end-page: 559 article-title: Calcineurin isessential for survival during membrane stress in Candida albicans publication-title: EMBO J – volume: 48 start-page: 1664 year: 2004 end-page: 1669 article-title: In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus publication-title: Antimicrob Agents Chemother – volume: 17 start-page: 81 year: 2001 end-page: 91 article-title: Current and future approaches to antimycotic treatment in the era of resistant fungi and immunocompromised hosts publication-title: Int J Antimicrob Agents – volume: 56 start-page: 1724 year: 2013 end-page: 1732 article-title: Increasing echinocandins resistance in Candida glabrata: Clinical failure correlates with presence or FKS mutations and elevate minimum inhibitory concentration publication-title: Clin Infect Dis – volume: 48 start-page: 503 year: 2009 end-page: 535 article-title: Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America publication-title: Clin Infect Dis – volume: 50 start-page: 1199 year: 2012 end-page: 1203 article-title: Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata publication-title: J Clin Microbiol – volume: 73 start-page: 5767 year: 2005 end-page: 5774 article-title: Calcineurin is required for Candida albicans to survive calcium stress in serum publication-title: Infect Immun – volume: 47 start-page: 956 year: 2003 end-page: 964 article-title: Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurina inhibitors against Candida albicans, Candida glabrata, and Candida krusei publication-title: Antimicrob Agents Chemother – volume: 18 start-page: 163 year: 2005 end-page: 194 article-title: Combination treatment of invasive fungal infections publication-title: Clin Microbiol Rev – volume: 43 start-page: 273 year: 2000 end-page: 279 article-title: Changes of virulence factors accompanying the phenomenon of induced fluconazole resistance in Candida albicans publication-title: Mycoses |
| SSID | ssj0025042 |
| Score | 2.2272117 |
| Snippet | In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of... In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of... |
| SourceID | scielo pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 125 |
| SubjectTerms | Antifungal Agents - pharmacology Azoles - pharmacology Candida glabrata - drug effects Candida glabrata - isolation & purification Candidiasis - microbiology Drug Resistance, Bacterial Drug Synergism Drug therapy Fungi Humans Infections Medical Microbiology Microbial Sensitivity Tests MICROBIOLOGY Studies Tacrolimus - pharmacology |
| SummonAdditionalLinks | – databaseName: ProQuest Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BAYkL4k2gICMhcQpNHL9yQqiiqjhwKZX2Fvm1YqXitCR7KH-Cv8yMk91lqcQtikdJnLE934w_zwC8i8YE2VpeRtX4UlAM3-kqlr7WhvJ7OR8z2-KrOj0XXxZyMQfchplWuVkT80Idek8x8qPaELptlJQfL69KqhpFu6tzCY3bcKfmlSJKl17sHC5Z5eI5aNRwJW4Mn0_wyLY6OtveFGjj6QSpEHzfNt0AnDd5k3fJTF38bZFOHsKDGUqyT5PuH8GtmB7Dvam45PUT-H12Tef6ciJmNtM2WL9ko_VUqefHemA2BWZ_9RcRr8YVmjg0F4xI5lRraWCrxJbEaE9ZphzWQ-bAuCwf9trQaScgmkZ2TOdkgmUIy9ERHy1b4egmQPsUzk8-fzs-LefyC6WXrRpLjTqMUYSlF7W3VplKOsmN5cLaynuCkrYRja8RQZlAW77km5latcErY0XzDA5Sn-ILYK7RxivpuA5BtEvlrFNGo7fnVajwaQV82Pz47nLKstGRd4Ka6rKmun80VcDhRj3dPOmGbjdECni7bcbpQnsgNsV-jTKaqtcJ7EcBzydtbt_IFee0IV-A3tPzVoBSce-3pNX3nJJbIG6qtCrg_TQidh-1-3xOwSXywbEP8uX_O_AK7pP4xKw8hIPx5zq-RvQzujd5iP8B9joCIg priority: 102 providerName: ProQuest |
| Title | Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26221097 https://www.proquest.com/docview/1803063655 https://search.proquest.com/docview/1700334528 https://pubmed.ncbi.nlm.nih.gov/PMC4512076 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100125&lng=en&tlng=en |
| Volume | 46 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbaAkfEu4GyMhISp-zm4VeOsGpVIVFVlEp7i_xaEWnXW5HsofwJ_jIzTrLt0hu3KLYSOzPOzGd_M0PIR6-U45UuUi9KmzLcwzcy86nNpcL8Xsb6yLa4EOfX7OuCLw4IH2NhImnfmmYaVutpaH5GbuXN2s5Gntjs8tucgZUC_D07JIegoCNEH1AWz2LFHLBk8PstVTGE7fAqm13tbjIw7Bg2yhiWsylEUeQx79N92_TA4XzIm3yMZmp13yKdPSNPB1eSfu6H_Jwc-PCCPOmLS96-JH-ubjGuLyZipgNtg26WtNMWK_Wsty3VwVH9e7PycNU1YOLAXFAkmWOtpZY2gS6R0R5in7TdtpEDY2J_t9cGoB0d0dDROcbJOE3BLQcg3mnagHajQ_uKXJ-d_pifp0P5hdTySnSpBBl6z9zSstxqLVTGDS-ULpjWmbXoSuqSlTYHD0o5PPJFbKZyUTkrlGbla3IUNsEfE2pKqazgppDOsWopjDZCSUB7VrgMnpaQ6fjh65s-y0aN6ASEVkeh1f8ILSEno3jqYdG1da4QAJWC84R82DXDcsEzEB38Zgt9JFavYzCPhLzppbl746gGCZF7ct51wFTc-y2goTEl96CRCfnUa8TdoO6GX-DmEmJwmAN_-9_veIdbC7gHhKTLE3LU_dr69-AYdWYCy2EhJ-TRl9OLy--TuCz-AsizDYo |
| link.rule.ids | 230,315,730,783,787,888,12068,21400,27936,27937,31731,31732,33756,33757,43322,43817,53804,53806 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BAbUXxLMEChgJiVNo4viVE0IV1QKll7bS3iLH9oqV2qQl2UP7J_jLzDjZXZZK3KJ4ktgZ2_ONPZ4P4H0wxsvS8jSowqWC1vBrnYXU5dpQfq_ahRhtcawmZ-LbVE7HBbduDKtczolxovatozXy_dwQui2UlJ8ur1JijaLd1ZFC4y7cozxcxGCgp2uHS2aRPAeNGs7EheHjCR5ZZvsnq5sCbTydIBWCb9qmW4DzdtzkfTJT539bpMNH8HCEkuzzoPvHcCc0T-DBQC55_RR-n1zTub6YiJmNYRusnbHeOmLquVh0zDae2Zv2POBVP0cTh-aCUZA5cS11bN6wGUW0N1Em7RZdjIGpo7zfKEOnnYBo07MDOifjLUNYjo54b9kcezcB2mdwdvjl9GCSjvQLqZOl6lONOgxB-JkTubNWmUzWkhvLhbWZcwQlbSEKlyOCMp62fMk3M7kqvVPGiuI5bDVtE14AqwttnJI1196LcqZqWyuj0dtzymf4tgQ-Ln98dTlk2ajIO0FNVVFT1T-aSmBvqZ5qHHRdte4iCbxbFeNwoT0Q24R2gTKa2OsEtiOB3UGbqy9yxTltyCegN_S8EqBU3JslzfxnTMktEDdlWiXwYegR60qtq89pcYl8cGyDfPn_BryF7cnpj6Pq6Ovx91ewQ48OUZZ7sNX_WoTXiIT6-k3s7n8AKQIFCQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagPNQLzwKBAkZC4pRsHrbjHNHCqryqSqVSxSXyK2LFbnbVZA_tn-hfZsZJtrvtrbcoHiWx8k1mPufzDCEfnZSWFyoNnchMyHANX-exC02SS6zvpY3zaotDcXDCvp_y041WX160b_Q0qmfzqJ7-9drK5dyMBp3Y6OjXmEGUAv49WtpqdJfcA5-NxUDUe67FY983B-IZfIQzmfabd3gRj47XJxmEd9w8yhg2tUlFmia--tNmhLqRdt5UT97HYDXbjEuTx-TPMKNOjvIvWrU6MhfXij3easpPyKM-W6WfO5On5I6rn5EHXf_K8-fk8vgctw76Ws-0V4bQRUVbZbAZ0HzVUFVbqi4WMwdH7RSiKEQkijp2bOfU0GlNKxTN194mbFaNl9lob2-3xs5cg7lu3dIxbsWxikLmD1y_VXQKDoQ58x45mXz9PT4I-w4PoeGFaMMcYOIcs5VhiVFKyJhrnkqVMqViYzBbVRnLTAJJmrT4Vxnpn0xEYY2QimUvyE69qN0rQnWWSyO4TnNrWVEJrbSQORBKI2wMVwtINLzVctkV8iiRAAEiSo-I8hoiArI_vPuy9-umTCRyrExwHpAP62HwSPzNomq3WIFNjg3yGMwjIC87qKzvOGAsIPkWiNYGWO17ewQQ4at-9wgIyKcOblcPdfX4Ka5fIc2HOfDXt77He_Lw6Muk_Pnt8McbsosX7SSe-2SnPVu5t5CGtfqdd7j_VSIvfw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synergistic+effects+of+tacrolimus+and+azole+antifungal+compounds+in+fluconazole-susceptible+and+fluconazole-resistant+Candida+glabrata+isolates&rft.jtitle=Brazilian+journal+of+microbiology&rft.au=Denardi%2C+Laura+Bedin&rft.au=Mario%2C+D%C3%A9bora+Alves+Nunes&rft.au=Loreto%2C+%C3%89rico+Silva&rft.au=Santurio%2C+Janio+Morais&rft.date=2015-05-01&rft.pub=Sociedade+Brasileira+de+Microbiologia&rft.issn=1678-4405&rft.volume=46&rft.issue=1&rft.spage=125&rft.epage=129&rft_id=info:doi/10.1590%2FS1517-838246120120442&rft.externalDocID=S1517_83822015000100125 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1678-4405&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1678-4405&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1678-4405&client=summon |