Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

• Published in: Nature reviews. Endocrinology Vol. 16; no. 5; pp. 276 - 283
• Main Authors: Hopkins, Benjamin D., Goncalves, Marcus D., Cantley, Lewis C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2020; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 631/45/275; 631/67/1059/153; 631/80/86/2369; 692/4028/67/2195; Animals; Biological Evolution; Cancer; Cellular signal transduction; Cytokines; Development and progression; Endocrine system; Endocrine System - metabolism; Endocrinology; Estrogens; Genetic aspects; Genetic transformation; Health aspects; Humans; Inflammation; Insulin; Insulin - metabolism; Kinases; Lipid kinase; Medicine; Medicine & Public Health; Metabolism; Metabolites; Molecular evolution; Neoplasms - metabolism; Nutrient status; Oncology, Experimental; Phenotypes; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Review Article; Signal Transduction; TOR protein; Transcription; Transferases; Tumorigenesis; Tumors; United States

Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic transformation. Although genetic alterations dominate the way cancer biologists think about oncogenesis, growing evidence suggests that systemic factors (for example, insulin, oestrogen and inflammatory cytokine...