Cytotoxic, Antitumor and Immunomodulatory Effects of the Water-Soluble Polysaccharides from Lotus (Nelumbo nucifera Gaertn.) Seeds

• Published in: Molecules (Basel, Switzerland) Vol. 21; no. 11; p. 1465
• Main Authors: Zheng, Yafeng, Wang, Qi, Zhuang, Weijing, Lu, Xu, Miron, Anca, Chai, Tsun-Thai, Zheng, Baodong, Xiao, Jianbo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2016; MDPI
• Subjects: Animals; Antiemetics; Antineoplastic Agents, Phytogenic - pharmacology; Antioxidants; antitumor; Biomarkers; Cancer; Cell growth; Cell Line, Tumor; Cytokines - blood; Cytokines - metabolism; Cytotoxicity; Diuretics; Fatty acids; Food; Herbal medicine; Humans; Immunologic Factors - pharmacology; Immunomodulation - drug effects; immunomodulatory; lotus seeds; Medicine; Mice; Nelumbo - chemistry; Nelumbo nucifera; Pharmacy; Physiology; Plant Extracts - pharmacology; Polyphenols; polysaccharides; Polysaccharides - pharmacology; Science; Seeds; Seeds - chemistry; Xenograft Model Antitumor Assays; China; Macao; polysaccharides; lotus seeds; antitumor; immunomodulatory

Lotus is an edible and medicinal plant, and the extracts from its different parts exhibit various bioactivities. In the present study, the hot water–soluble polysaccharides from lotus seeds (LSPS) were evaluated for their cancer cell cytotoxicity, immunomodulatory and antitumor activities. LSPS show...