revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases

Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion...

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Published inJournal of lipid research Vol. 46; no. 9; pp. 2029 - 2032
Main Authors Hunt, Mary C, Yamada, Junji, Maltais, Lois J, Wright, Mathew W, Podesta, Ernesto J, Alexson, Stefan E. H
Format Journal Article
LanguageEnglish
Published United States Elsevier 01.09.2005
Subjects
Alternative Splicing
Animals
coenzyme A
fatty acid metabolism
Humans
Medicin och hälsovetenskap
Mice
Multigene Family
Palmitoyl-CoA Hydrolase - genetics
peroxisomes
Rats
Terminology as Topic
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Summary:Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee and the Mouse Genomic Nomenclature Committee, a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged.
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ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.E500003-JLR200