Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study

• Published in: The lancet oncology Vol. 19; no. 3; pp. 382 - 393
• Main Authors: Tang, Xin-Ran, Li, Ying-Qin, Liang, Shao-Bo, Jiang, Wei, Liu, Fang, Ge, Wen-Xiu, Tang, Ling-Long, Mao, Yan-Ping, He, Qing-Mei, Yang, Xiao-Jing, Zhang, Yuan, Wen, Xin, Zhang, Jian, Wang, Ya-Qin, Zhang, Pan-Pan, Sun, Ying, Yun, Jing-Ping, Zeng, Jing, Li, Li, Liu, Li-Zhi, Liu, Na, Ma, Jun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2018; Elsevier Limited
• Subjects: Biomarkers; Biopsy; Cancer therapies; Chemoradiotherapy; Chemotherapy; Clinical outcomes; Cohort analysis; Dehydrogenases; Deoxyribonucleic acid; DNA; DNA methylation; DNA microarrays; DNA viruses; Epstein-Barr virus; Gene expression; Health risk assessment; Hematology, Oncology, and Palliative Medicine; Medical imaging; Medical innovations; Medical prognosis; Metastases; Metastasis; Nasopharyngeal carcinoma; Nomograms; Oncology; Patients; Quality control; Radiation therapy; Risk assessment; Risk groups; Survival; Throat cancer; Tumor necrosis factor-TNF; Tumors; United States > US; China

Gene expression patterns can be used as prognostic biomarkers in various types of cancers. We aimed to identify a gene expression pattern for individual distant metastatic risk assessment in patients with locoregionally advanced nasopharyngeal carcinoma. In this multicentre, retrospective, cohort an...