A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects

Background/Objectives: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of...

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Published inEuropean journal of clinical nutrition Vol. 70; no. 1; pp. 10 - 16
Main Authors Biesinger, S, Michaels, H A, Quadros, A S, Qian, Y, Rabovsky, A B, Badger, R S, Jalili, T
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2016
Nature Publishing Group
Subjects
692/308/2779/777
692/699/75/243
692/700/565/2072
Adult
Antihypertensive Agents - isolation & purification
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Antioxidants - isolation & purification
Antioxidants - pharmacology
Antioxidants - therapeutic use
Blood pressure
Blood Pressure - drug effects
Clinical Nutrition
Control
Cross-Over Studies
Dietary Supplements
Double-Blind Method
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Enzymatic activity
Epidemiology
Female
Green tea
Health aspects
Humans
Hypertension
Hypertension - blood
Hypertension - drug therapy
Insulin
Internal Medicine
Magnoliopsida - chemistry
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Metabolic Syndrome - blood
Metabolic Syndrome - drug therapy
Metabolic Syndrome - pathology
Metabolites
Middle Aged
Nitrates
Nitric oxide
Nitric Oxide - biosynthesis
Nitric Oxide Synthase Type III - blood
Nitrites
Nutrition research
original-article
Phytochemicals
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Phytochemicals - therapeutic use
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polyphenols - isolation & purification
Polyphenols - pharmacology
Polyphenols - therapeutic use
Prevention
Properties
Public Health
Quercetin - isolation & purification
Quercetin - pharmacology
Quercetin - therapeutic use
Stilbenes - isolation & purification
Stilbenes - pharmacology
Stilbenes - therapeutic use
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Abstract Background/Objectives: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects. Subjects/Methods: Eighteen individuals meeting BP requirements (⩾130 mm Hg systolic or ⩾85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14 -h daytime ambulatory BP was assessed at baseline and at the end point of each arm. Results: BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4 mm Hg ( P =0.024, 95% CI, 0.6–8.1), systolic pressure was unchanged and mean arterial pressure trended ( P =0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary nitrate and nitrite concentrations were significantly increased ( P =0.022) after supplementation. Human aortic endothelial cells treated with metabolites of the polyphenols used in the human supplement trial had a significant increase ( P =0.005) in insulin-stimulated eNOS phosphorylation and greater ( P <0.001) accumulation of nitrates/nitrites. Conclusions: Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.
AbstractList BACKGROUND/OBJECTIVES: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects. SUBJECTS/METHODS: Eighteen individuals meeting BP requirements (≥ 130 mm Hg systolic or ≥ 85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14-h daytime ambulatory BP was assessed at baseline and at the end point of each arm. RESULTS: BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4 mm Hg (P = 0.024, 95% CI, 0.6-8.1), systolic pressure was unchanged and mean arterial pressure trended (P = 0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary nitrate and nitrite concentrations were significantly increased (P = 0.022) after supplementation. Human aortic endothelial cells treated with metabolites of the polyphenols used in the human supplement trial had a significant increase (P = 0.005) in insulin-stimulated eNOS phosphorylation and greater (P < 0.001) accumulation of nitrates/nitrites. CONCLUSIONS: Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP. doi:10.1038/ejcn.2015.88;published online 10 June 2015
SUBJECTS/METHODS: Eighteen individuals meeting BP requirements (≥ 130 mm Hg systolic or ≥ 85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14-h daytime ambulatory BP was assessed at baseline and at the end point of each arm. doi:10.1038/ejcn.2015.88;published online 10 June 2015
Background/Objectives: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects. Subjects/Methods: Eighteen individuals meeting BP requirements (⩾130 mm Hg systolic or ⩾85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14 -h daytime ambulatory BP was assessed at baseline and at the end point of each arm. Results: BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4 mm Hg ( P =0.024, 95% CI, 0.6–8.1), systolic pressure was unchanged and mean arterial pressure trended ( P =0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary nitrate and nitrite concentrations were significantly increased ( P =0.022) after supplementation. Human aortic endothelial cells treated with metabolites of the polyphenols used in the human supplement trial had a significant increase ( P =0.005) in insulin-stimulated eNOS phosphorylation and greater ( P <0.001) accumulation of nitrates/nitrites. Conclusions: Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.
BACKGROUND/OBJECTIVESIsolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects.SUBJECTS/METHODSEighteen individuals meeting BP requirements (⩾130 mm Hg systolic or ⩾85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14 -h daytime ambulatory BP was assessed at baseline and at the end point of each arm.RESULTSBP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4 mm Hg (P=0.024, 95% CI, 0.6-8.1), systolic pressure was unchanged and mean arterial pressure trended (P=0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary nitrate and nitrite concentrations were significantly increased (P=0.022) after supplementation. Human aortic endothelial cells treated with metabolites of the polyphenols used in the human supplement trial had a significant increase (P=0.005) in insulin-stimulated eNOS phosphorylation and greater (P<0.001) accumulation of nitrates/nitrites.CONCLUSIONSOur clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.
Background/ Objectives: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects.Subjects/ Methods: Eighteen individuals meeting BP requirements ([egs]130 mm Hg systolic or [egs]85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14 -h daytime ambulatory BP was assessed at baseline and at the end point of each arm. Results: BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4 mm Hg (P=0.024, 95% CI, 0.6-8.1), systolic pressure was unchanged and mean arterial pressure trended (P=0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary nitrate and nitrite concentrations were significantly increased (P=0.022) after supplementation. Human aortic endothelial cells treated with metabolites of the polyphenols used in the human supplement trial had a significant increase (P=0.005) in insulin-stimulated eNOS phosphorylation and greater (P<0.001) accumulation of nitrates/nitrites. Conclusions: Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.
Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects. Eighteen individuals meeting BP requirements (⩾130 mm Hg systolic or ⩾85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14 -h daytime ambulatory BP was assessed at baseline and at the end point of each arm. BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4 mm Hg (P=0.024, 95% CI, 0.6-8.1), systolic pressure was unchanged and mean arterial pressure trended (P=0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary nitrate and nitrite concentrations were significantly increased (P=0.022) after supplementation. Human aortic endothelial cells treated with metabolites of the polyphenols used in the human supplement trial had a significant increase (P=0.005) in insulin-stimulated eNOS phosphorylation and greater (P<0.001) accumulation of nitrates/nitrites. Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.
BACKGROUND/OBJECTIVES: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized that a combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg) and a blend of quercetin, ginkgo biloba and bilberry (60 mg) would reduce blood pressure (BP) in hypertensive subjects. SUBJECTS/METHODS: Eighteen individuals meeting BP requirements (130 mm Hg systolic or 85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14 -h daytime ambulatory BP was assessed at baseline and at the end point of each arm. RESULTS: BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4 mm Hg (P = 0.024, 95% CI, 0.68.1), systolic pressure was unchanged and mean arterial pressure trended (P = 0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary nitrate and nitrite concentrations were signicantly increased (P = 0.022) after supplementation. Human aortic endothelial cells treated with metabolites of the polyphenols used in the human supplement trial had a signicant increase (P = 0.005) in insulin-stimulated eNOS phosphorylation and greater (Po0.001) accumulation of nitrates/nitrites. CONCLUSIONS: Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.
Audience Professional
Academic
Author Michaels, H A
Biesinger, S
Jalili, T
Rabovsky, A B
Badger, R S
Quadros, A S
Qian, Y
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  organization: Division of Nutrition, University of Utah
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  surname: Quadros
  fullname: Quadros, A S
  organization: Division of Nutrition, University of Utah
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  surname: Qian
  fullname: Qian, Y
  organization: Division of Nutrition, University of Utah
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  surname: Rabovsky
  fullname: Rabovsky, A B
  organization: Research and Technology Development, Melaleuca Inc
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  fullname: Jalili, T
  email: thunder.jalili@utah.edu
  organization: Division of Nutrition, University of Utah
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26059745$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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DOI 10.1038/ejcn.2015.88
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Snippet Background/Objectives: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in...
Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in humans. We hypothesized...
BACKGROUND/OBJECTIVES: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in...
SUBJECTS/METHODS: Eighteen individuals meeting BP requirements (≥ 130 mm Hg systolic or ≥ 85 mm Hg diastolic) and criteria for metabolic syndrome were enrolled...
BACKGROUND/OBJECTIVESIsolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in...
Background/ Objectives: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in...
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SubjectTerms 692/308/2779/777
692/699/75/243
692/700/565/2072
Adult
Antihypertensive Agents - isolation & purification
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Antioxidants - isolation & purification
Antioxidants - pharmacology
Antioxidants - therapeutic use
Blood pressure
Blood Pressure - drug effects
Clinical Nutrition
Control
Cross-Over Studies
Dietary Supplements
Double-Blind Method
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Enzymatic activity
Epidemiology
Female
Green tea
Health aspects
Humans
Hypertension
Hypertension - blood
Hypertension - drug therapy
Insulin
Internal Medicine
Magnoliopsida - chemistry
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Metabolic Syndrome - blood
Metabolic Syndrome - drug therapy
Metabolic Syndrome - pathology
Metabolites
Middle Aged
Nitrates
Nitric oxide
Nitric Oxide - biosynthesis
Nitric Oxide Synthase Type III - blood
Nitrites
Nutrition research
original-article
Phytochemicals
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Phytochemicals - therapeutic use
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polyphenols - isolation & purification
Polyphenols - pharmacology
Polyphenols - therapeutic use
Prevention
Properties
Public Health
Quercetin - isolation & purification
Quercetin - pharmacology
Quercetin - therapeutic use
Stilbenes - isolation & purification
Stilbenes - pharmacology
Stilbenes - therapeutic use
Title A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects
URI https://link.springer.com/article/10.1038/ejcn.2015.88
https://www.ncbi.nlm.nih.gov/pubmed/26059745
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