highly sensitive LC-MS/MS method capable of simultaneously quantitating celiprolol and atenolol in human plasma for a cassette cold-microdosing study - Minamide, Yoshiyuki; Osawa, Yukio; Nishida, Hiroshi; Igarashi, Harue; Kudoh, Shinobu (Journal of separation science, 2011)
Keywords: Analysis; Antihypertensive Agents; Antihypertensive Agents - blood; Antihypertensive Agents - isolation & purification; Atenolol; Atenolol - blood; Atenolol - isolation & purification; beta-adrenergic antagonists; Biological and medical sciences; blood; Cartridges; Cassettes; cation exchange; Celiprolol; Celiprolol - blood; Celiprolol - isolation & purification; Chromatography; Chromatography, High Pressure Liquid; Chromatography, High Pressure Liquid - methods; Dispersion hardening alloys; Extraction; formic acid; General pharmacology; Human; Humans; ionization; isolation & purification; LC-MS; mass spectrometry; Medical sciences; methanol; methods; Methyl alcohol; Microdosing; Pharmacology. Drug treatments; reversed-phase chromatography; reversed-phase liquid chromatography; Sensitivity and Specificity; Separation; Solid Phase Extraction - methods; Solid-phase extraction; spectrometers; Tandem Mass Spectrometry; Tandem Mass Spectrometry - methods; β-blocker; Solid phase extraction; Biological fluid; Tandem mass spectrometry; Chemical analysis; Vasodilator agent; Celiprolol; HPLC chromatography; Electrospray; Blood; Microdosing; Chemical enrichment; Blood plasma; β1-Adrenergic receptor; Sample preparation; Antagonist; Quantitative analysis; Trace analysis; Human; Validation; Healthy subject; Coupled method; MS; Oral administration; Atenolol; Solid-phase extraction; β-blocker; Reversed phase chromatography; LC-MS; Simultaneous measurement; Antihypertensive agent; Pharmacokinetics; Cation exchanger; Beta blocking agent