Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

• Published in: Advanced science Vol. 8; no. 16; pp. e2101090 - n/a
• Main Authors: Li, Jia, Zheng, Meng, Shimoni, Olga, Banks, William A., Bush, Ashley I., Gamble, Jennifer R., Shi, Bingyang
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2021; John Wiley and Sons Inc; Wiley
• Subjects: Alzheimer's disease; Animals; Biological Transport; Blood-Brain Barrier - metabolism; blood–brain barrier; brain diseases; DNA methylation; Drug Carriers - administration & dosage; drug delivery; Drug Delivery Systems; Drugs; Endothelium; Gene expression; Humans; Inflammation; Mice; nanomedicine; Nanoparticle Drug Delivery System - administration & dosage; nanotechnology; Proteins; Review; Reviews; Veins & arteries; blood-brain barrier; nanotechnology; nanomedicine; drug delivery; brain diseases

The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from entering the brain. An intact BBB is also critical for the maintenance of normal neuronal function. In cerebral vas...