Effect of Genetic Variations in Syntaxin-Binding Protein-5 and Syntaxin-2 on von Willebrand Factor Concentration and Cardiovascular Risk

• Published in: Circulation. Cardiovascular genetics Vol. 3; no. 6; pp. 507 - 512
• Main Authors: van Loon, Janine E., Leebeek, Frank W.G., Deckers, Jaap W., Dippel, Diederik W.J., Poldermans, Don, Strachan, David P., Tang, Weihong, OʼDonnell, Christopher J., Smith, Nicholas L., de Maat, Moniek P.M.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.12.2010; Lippincott Williams & Wilkins
• Subjects: Adult; Age of Onset; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Case-Control Studies; Collagen - metabolism; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Humans; Male; Medical sciences; Middle Aged; Nerve Tissue Proteins - genetics; Polymorphism, Single Nucleotide; Protein Binding; R-SNARE Proteins - genetics; Risk; Syntaxin 1 - genetics; Thrombosis - diagnosis; Thrombosis - etiology; von Willebrand Factor - analysis; von Willebrand Factor - metabolism; Genetic variability; Pathogenesis; Sex; Check; Activity; Cardiovascular disease; Risk; Genetic determinism; Metaanalysis; Blood plasma; Arterial disease; Vascular disease; Binding protein; Association; Gene; von Willebrand factor; Atherosclerosis; Genetics; STXBP5; STX2; Haplotype; Age; Human; Concentration factor; Secretion; Genetic variant; Method; cardiovascular diseases; Antigen; Collagen; Risk factor; Tagging; Technique; Artery thrombosis; Willebrand factor; Genome

BACKGROUND—Elevated von Willebrand factor (VWF) plasma levels are associated with an increased risk of cardiovascular disease. A meta-analysis of genomewide association studies on VWF identified novel candidate genes, that is, syntaxin-binding protein 5 (STXBP5) and syntaxin 2 (STX2), which are poss...