Role of activation‐induced cytidine deaminase in the progression of follicular lymphoma

• Published in: Cancer science Vol. 103; no. 3; pp. 415 - 421
• Main Authors: Shikata, Hisaharu, Yakushijin, Yoshihiro, Matsushita, Natsuki, Sakai, Akira, Sugita, Atsuro, Nakamura, Naoya, Yamanouchi, Jun, Azuma, Taichi, Hato, Takaaki, Yasukawa, Masaki
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2012
• Subjects: Activation-induced cytidine deaminase; Adult; Aged; Blotting, Western; c-Myc protein; Cancer; Cell Proliferation; Cell survival; Class switching; Cytidine Deaminase - genetics; Cytidine Deaminase - metabolism; Disease Progression; double prime B-cell lymphoma; Enzyme Activation; Female; Gene Expression Profiling; Humans; Immunoglobulins; Immunohistochemistry; Lymphoma, Follicular - genetics; Lymphoma, Follicular - metabolism; Lymphoma, Follicular - pathology; Male; Middle Aged; Original; Polymerase chain reaction; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Real-Time Polymerase Chain Reaction; Recombination; Reverse Transcriptase Polymerase Chain Reaction; somatic hypermutation; Transcription; Transfection; Translocation

Activation‐induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class‐switch recombination of the immunoglobulin gene, and for c‐myc translocation of germinal center‐derived B‐cell lymphoma. In the present study, we attempted to clarify the significance of AID associated...