Role of activation‐induced cytidine deaminase in the progression of follicular lymphoma

Activation‐induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class‐switch recombination of the immunoglobulin gene, and for c‐myc translocation of germinal center‐derived B‐cell lymphoma. In the present study, we attempted to clarify the significance of AID associated...

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Published inCancer science Vol. 103; no. 3; pp. 415 - 421
Main Authors Shikata, Hisaharu, Yakushijin, Yoshihiro, Matsushita, Natsuki, Sakai, Akira, Sugita, Atsuro, Nakamura, Naoya, Yamanouchi, Jun, Azuma, Taichi, Hato, Takaaki, Yasukawa, Masaki
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.2012
Subjects
Activation-induced cytidine deaminase
Adult
Aged
Blotting, Western
c-Myc protein
Cancer
Cell Proliferation
Cell survival
Class switching
Cytidine Deaminase - genetics
Cytidine Deaminase - metabolism
Disease Progression
double prime B-cell lymphoma
Enzyme Activation
Female
Gene Expression Profiling
Humans
Immunoglobulins
Immunohistochemistry
Lymphoma, Follicular - genetics
Lymphoma, Follicular - metabolism
Lymphoma, Follicular - pathology
Male
Middle Aged
Original
Polymerase chain reaction
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Real-Time Polymerase Chain Reaction
Recombination
Reverse Transcriptase Polymerase Chain Reaction
somatic hypermutation
Transcription
Transfection
Translocation
Online AccessGet full text
ISSN1347-9032
1349-7006
1349-7006
DOI10.1111/j.1349-7006.2011.02186.x

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Abstract Activation‐induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class‐switch recombination of the immunoglobulin gene, and for c‐myc translocation of germinal center‐derived B‐cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c‐myc in the progression of follicular lymphoma (FL) using RT‐PCR and quantitative real‐time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c‐myc and AID. The samples taken from a patient with FL who died within 2 years after the start of treatment showed either no or low expression of AID, despite expressing high levels of c‐myc. In order to examine the role of AID expression in rapidly progressive FL, the full‐length AID transcript was transfected into AID‐negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID‐expressing transfectants with a low proliferation rate and a significantly increased incidence of G0/G1 arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c‐myc is expressed. Switch‐off or low expression of AID after c‐myc amplification may correlate with the clinical outcomes of FL. (Cancer Sci 2012; 103: 415–421)
AbstractList Activation‐induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class‐switch recombination of the immunoglobulin gene, and for c‐myc translocation of germinal center‐derived B‐cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c‐myc in the progression of follicular lymphoma (FL) using RT‐PCR and quantitative real‐time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c‐myc and AID . The samples taken from a patient with FL who died within 2 years after the start of treatment showed either no or low expression of AID , despite expressing high levels of c‐myc . In order to examine the role of AID expression in rapidly progressive FL, the full‐length AID transcript was transfected into AID ‐negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID ‐expressing transfectants with a low proliferation rate and a significantly increased incidence of G 0 /G 1 arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c‐myc is expressed. Switch‐off or low expression of AID after c‐myc amplification may correlate with the clinical outcomes of FL. ( Cancer Sci 2012; 103: 415–421)
Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class-switch recombination of the immunoglobulin gene, and for c-myc translocation of germinal center-derived B-cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c-myc in the progression of follicular lymphoma (FL) using RT-PCR and quantitative real-time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c-myc and AID. The samples taken from a patient with FL who died within 2 years after the start of treatment showed either no or low expression of AID, despite expressing high levels of c-myc. In order to examine the role of AID expression in rapidly progressive FL, the full-length AID transcript was transfected into AID-negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID-expressing transfectants with a low proliferation rate and a significantly increased incidence of G(0)/G(1) arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c-myc is expressed. Switch-off or low expression of AID after c-myc amplification may correlate with the clinical outcomes of FL.
Activation‐induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class‐switch recombination of the immunoglobulin gene, and for c‐myc translocation of germinal center‐derived B‐cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c‐myc in the progression of follicular lymphoma (FL) using RT‐PCR and quantitative real‐time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c‐myc and AID. The samples taken from a patient with FL who died within 2 years after the start of treatment showed either no or low expression of AID, despite expressing high levels of c‐myc. In order to examine the role of AID expression in rapidly progressive FL, the full‐length AID transcript was transfected into AID‐negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID‐expressing transfectants with a low proliferation rate and a significantly increased incidence of G0/G1 arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c‐myc is expressed. Switch‐off or low expression of AID after c‐myc amplification may correlate with the clinical outcomes of FL. (Cancer Sci 2012; 103: 415–421)
Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class-switch recombination of the immunoglobulin gene, and for c-myc translocation of germinal center-derived B-cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c-myc in the progression of follicular lymphoma (FL) using RT-PCR and quantitative real-time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c-myc and AID. The samples taken from a patient with FL who died within 2years after the start of treatment showed either no or low expression of AID, despite expressing high levels of c-myc. In order to examine the role of AID expression in rapidly progressive FL, the full-length AID transcript was transfected into AID-negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID-expressing transfectants with a low proliferation rate and a significantly increased incidence of G0/G1 arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c-myc is expressed. Switch-off or low expression of AID after c-myc amplification may correlate with the clinical outcomes of FL. (Cancer Sci 2012; 103: 415-421)
Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class-switch recombination of the immunoglobulin gene, and for c-myc translocation of germinal center-derived B-cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c-myc in the progression of follicular lymphoma (FL) using RT-PCR and quantitative real-time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c-myc and AID. The samples taken from a patient with FL who died within 2 years after the start of treatment showed either no or low expression of AID, despite expressing high levels of c-myc. In order to examine the role of AID expression in rapidly progressive FL, the full-length AID transcript was transfected into AID-negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID-expressing transfectants with a low proliferation rate and a significantly increased incidence of G(0)/G(1) arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c-myc is expressed. Switch-off or low expression of AID after c-myc amplification may correlate with the clinical outcomes of FL.Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class-switch recombination of the immunoglobulin gene, and for c-myc translocation of germinal center-derived B-cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c-myc in the progression of follicular lymphoma (FL) using RT-PCR and quantitative real-time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c-myc and AID. The samples taken from a patient with FL who died within 2 years after the start of treatment showed either no or low expression of AID, despite expressing high levels of c-myc. In order to examine the role of AID expression in rapidly progressive FL, the full-length AID transcript was transfected into AID-negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID-expressing transfectants with a low proliferation rate and a significantly increased incidence of G(0)/G(1) arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c-myc is expressed. Switch-off or low expression of AID after c-myc amplification may correlate with the clinical outcomes of FL.
Author Yamanouchi, Jun
Sugita, Atsuro
Matsushita, Natsuki
Nakamura, Naoya
Yakushijin, Yoshihiro
Sakai, Akira
Hato, Takaaki
Azuma, Taichi
Yasukawa, Masaki
Shikata, Hisaharu
AuthorAffiliation 4 Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University Graduate School of Medicine, Hiroshima
6 Department of Pathology, Tokai University School of Medicine, Isehara
1 Department of Bioregulatory Medicine
3 Functional Genomics Core Laboratory, Ehime University Proteo‐Medicine Research Center, Toon
7 Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Ehime University Graduate School of Medicine, Toon; Japan
2 Cancer Center, Ehime University Hospital, Ehime University Graduate School of Medicine, Toon
5 Department of Pathology, Ehime University Hospital, Ehime University Graduate School of Medicine, Toon
AuthorAffiliation_xml – name: 7 Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Ehime University Graduate School of Medicine, Toon; Japan
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– name: 6 Department of Pathology, Tokai University School of Medicine, Isehara
– name: 5 Department of Pathology, Ehime University Hospital, Ehime University Graduate School of Medicine, Toon
– name: 2 Cancer Center, Ehime University Hospital, Ehime University Graduate School of Medicine, Toon
– name: 4 Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University Graduate School of Medicine, Hiroshima
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Snippet Activation‐induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class‐switch recombination of the immunoglobulin gene, and for...
Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hypermutation and class-switch recombination of the immunoglobulin gene, and for...
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SubjectTerms Activation-induced cytidine deaminase
Adult
Aged
Blotting, Western
c-Myc protein
Cancer
Cell Proliferation
Cell survival
Class switching
Cytidine Deaminase - genetics
Cytidine Deaminase - metabolism
Disease Progression
double prime B-cell lymphoma
Enzyme Activation
Female
Gene Expression Profiling
Humans
Immunoglobulins
Immunohistochemistry
Lymphoma, Follicular - genetics
Lymphoma, Follicular - metabolism
Lymphoma, Follicular - pathology
Male
Middle Aged
Original
Polymerase chain reaction
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Real-Time Polymerase Chain Reaction
Recombination
Reverse Transcriptase Polymerase Chain Reaction
somatic hypermutation
Transcription
Transfection
Translocation
Title Role of activation‐induced cytidine deaminase in the progression of follicular lymphoma
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2011.02186.x
https://www.ncbi.nlm.nih.gov/pubmed/22168746
https://www.proquest.com/docview/1020856918
https://www.proquest.com/docview/993104894
https://pubmed.ncbi.nlm.nih.gov/PMC7713616
Volume 103
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