微创颅内血肿抽吸引流术对幕上脑出血患者颅内压的影响

目的:观察微创颅内血肿抽吸引流术对幕上脑出血患者颅内压的影响,从而进一步评估该治疗方法的疗效。方法选择2013年4月~2014年12月行微创颅内血肿抽吸引流术治疗幕上脑出血患者,观察患者手术前后颅内压变化及早期预后情况。结果共入组53例患者,术后14 d/出院Glasgow意识障碍量表(Glasgow Coma Scale,GCS)评分显著高于术前[7(12(9,15)vs 7(5,11),Z=-5.057,P<0.001],美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分低于术前[14(11,18)vs 19(...

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Published in中国卒中杂志 Vol. 10; no. 5; pp. 401 - 406
Main Author 杨骏 杨波 杨中华 陈胜云 赵性泉
Format Journal Article
LanguageChinese
Published 100050 北京首都医科大学附属北京天坛医院神经内科,国家神经系统疾病临床医学研究中心,北京脑重大疾病研究院脑卒中研究所,脑血管病转化医学北京市重点实验室 2015
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Summary:目的:观察微创颅内血肿抽吸引流术对幕上脑出血患者颅内压的影响,从而进一步评估该治疗方法的疗效。方法选择2013年4月~2014年12月行微创颅内血肿抽吸引流术治疗幕上脑出血患者,观察患者手术前后颅内压变化及早期预后情况。结果共入组53例患者,术后14 d/出院Glasgow意识障碍量表(Glasgow Coma Scale,GCS)评分显著高于术前[7(12(9,15)vs 7(5,11),Z=-5.057,P<0.001],美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分低于术前[14(11,18)vs 19(15,23),Z=-4.210,P<0.001]。终点血肿体积较基线减小[17.2(11.8,25.8)mlvs 67.5(48.2,82.2)ml,Z=-6.048,P<0.001]。其中29例患者行颅内压监测,结果显示术后颅内压较术前颅内压降低[14(9.5,21.5) mmHgvs 30(21.5,40)mmHg,Z=-4.705,P<0.001],但颅内压降低率与首次血肿抽吸率之间无相关性(r=0.162,P=0.401)。行颅内压监测的患者早期预后良好组与不良组的术前颅内压、术后颅内压、颅内压降低量、颅内压降低率无显著差异。结论微创颅内血肿抽吸引流术治疗幕上脑出血有效,可改善早期神经功能预后,减轻血肿占位效应,并显著降低颅内压。术前后颅内压及术中颅内压变化对于脑出血早期预后的影响不明显。
Bibliography:11-5434/R
Objective To observe the effect of minimal invasive hematoma aspiration on intracranial pressure in patients with supratentorial intracerebral hemorrhage and evaluating the efifcacy of this treatment. Methods Patients who were underwent minimal invasive hematoma aspiration were recruited from Apr. 2013 to Dec. 2014. We observed the intracranial pressure (ICP) change before and after the surgery and early neurological outcomes of these subjects. Results Fifty-three patients were recruited. At the 14th day after the operation/discharge day, the GCS score was signiifcantly higher than the baseline (7[5, 11]vs 12[9, 15],Z=-5.057,P〈0.001), and the National Institutes of Health Stroke Scale (NIHSS) score was lower than the baseline (19[15, 23]vs 14[11, 18],Z=-4.210,P〈0.001). The hematoma volume of the end of treatment was obviously less than the baseline (67.5[48.2, 82.2]mlvs 17.2[11.8, 25.8]ml,Z=-6.048,P〈0.001). 29 subjects were underwent intracranial pressure monitor before the surgery. The postoperative
ISSN:1673-5765
DOI:10.3969/j.issn.1673-5765.2015.05.005