A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example

• Published in: Chinese medicine Vol. 18; no. 1; pp. 40 - 18
• Main Authors: Hu, En, Li, Zhilin, Li, Teng, Yang, Xueping, Ding, Ruoqi, Jiang, Haoying, Su, Hong, Cheng, Menghan, Yu, Zhe, Li, Haigang, Tang, Tao, Wang, Yang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.04.2023; BioMed Central; BMC
• Subjects: Animal experimentation; Animal research; Astragaloside IV; Bioavailability; Biotransformation; Blood-brain barrier; Cdc42 protein; FDA approval; Genes; Gut microbiota; Health aspects; Hemorrhage; Herbal products; Intestinal microflora; Intracerebral hemorrhage; Leukocyte migration; Ligands; Liver; Macrophages; Mathematical models; Medicine, Botanic; Medicine, Herbal; Membrane permeability; Metabolism; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Microglia; Molecular dynamics; Nervous system diseases; Network pharmacology; Neurological diseases; Permeability; Pharmacology; Proteins; Simulation; Stroke; Traditional Chinese medicine; Tumor necrosis factor-α; China; Beijing China; United States > US; Gut microbiota; Herbal products; Cycloastragenol; Biotransformation; Liver; Network pharmacology; Astragaloside IV; 3-epi-cycloastragenol; Intracerebral hemorrhage; Microglia

The oral bioavailability and blood-brain barrier permeability of many herbal products are too low to explain the significant efficacy fully. Gut microbiota and liver can metabolize herbal ingredients to more absorbable forms. The current study aims to evaluate the ability of a novel biotransformatio...