Do iron homeostasis biomarkers mediate the associations of liability to type 2 diabetes and glycemic traits in liver steatosis and cirrhosis: a two-step Mendelian randomization study - Liang, Ying; Luo, Shan; Bell, Steven; Mo, Jacky Man Yuen; He, Baoting; Zhou, Yangzhong; Bai, Xiaoyin; Au Yeung, Shiu Lun (BMC medicine, 2024)
Keywords: Alanine; Alanine transaminase; Biological markers; Biomarkers; Biomarkers - blood; Blood Glucose - metabolism; Cardiovascular disease; Cirrhosis; Consortia; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Estimates; Fatty liver; Fatty Liver - genetics; Ferritin; Genetic analysis; Genetic aspects; Genome-wide association studies; Genome-Wide Association Study; Genomics; Glucose; Glycemic traits; Health aspects; Homeostasis; Humans; Insulin; Insulin resistance; Iron; Iron - blood; Iron - metabolism; Iron compounds; Liability; Liability (Law); Liver; Liver cirrhosis; Liver Cirrhosis - genetics; Liver diseases; Liver iron; Liver steatosis; Magnetic resonance imaging; Mediation; Medical research; Medicine, Experimental; Mendelian Randomization Analysis; Meta-analysis; Observational studies; Physiological aspects; Proton density (concentration); Randomization; Risk; Sensitivity analysis; Statistical analysis; Steatosis; Type 2 diabetes; Variance analysis; China; Type 2 diabetes; Ferritin; Glycemic traits; Insulin; Liver cirrhosis; Liver iron; Liver steatosis