Global changes in DNA methylation in Alzheimer’s disease peripheral blood mononuclear cells

• Published in: Brain, behavior, and immunity Vol. 45; pp. 139 - 144
• Main Authors: Di Francesco, Andrea, Arosio, Beatrice, Falconi, Anastasia, Micioni Di Bonaventura, Maria Vittoria, Karimi, Mohsen, Mari, Daniela, Casati, Martina, Maccarrone, Mauro, D’Addario, Claudio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2015
• Subjects: Aged; Aged, 80 and over; Allergy and Immunology; Alzheimer Disease - genetics; Alzheimer’s disease; APOE; Apolipoprotein E4 - genetics; Case-Control Studies; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA methylation; DNA Methylation - genetics; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNMT; Epigenesis, Genetic; Epigenetics; Female; Humans; Italy; Leukocytes, Mononuclear - metabolism; Male; PBMC; Peripheral markers; Psychiatry; Pyrosequencing; Severity of Illness Index; White People - genetics; Italy; DNMT; Alzheimer’s disease; Pyrosequencing; DNA methylation; Epigenetics; Peripheral markers; APOE; PBMC

•DNA methylation is increased in peripheral cells of Alzheimer’s disease patients.•DNA methylation correlates with worse cognitive performances and APOE ε4 polymorphism.•Global DNA hypermethylation is a peripheral marker of Alzheimer’s disease. Changes in epigenetic marks may help explain the late o...