Fine Functional Organization of Auditory Cortex Revealed by Fourier Optical Imaging

We provide an overall view of the functional tonotopic organization of the auditory cortex in the rat. We apply a recently developed technique for acquiring intrinsic signal optical maps, Fourier imaging, in the rat auditory cortex. These highly detailed maps, derived in a several-minute-long record...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 102; no. 37; pp. 13325 - 13330
Main Authors Kalatsky, Valery A., Polley, Daniel B., Merzenich, Michael M., Schreiner, Christoph E., Stryker, Michael P.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 13.09.2005
National Acad Sciences
Subjects
Animals
Auditory cortex
Auditory Cortex - anatomy & histology
Biological Sciences
Brain
Brain Mapping - methods
Diagnostic Imaging - methods
Diagnostic Imaging - standards
Document imaging
Ears & hearing
Electrophysiology
Female
Fourier Analysis
Hemodynamics
Imaging
Male
Medical imaging
Methods
Neurology
Neurons
Neuroscience
Octaves
Rats
Rats, Sprague-Dawley
Rodents
Ultrasonography
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Summary:We provide an overall view of the functional tonotopic organization of the auditory cortex in the rat. We apply a recently developed technique for acquiring intrinsic signal optical maps, Fourier imaging, in the rat auditory cortex. These highly detailed maps, derived in a several-minute-long recording procedure, delineate multiple auditory cortical areas and demonstrate their shapes, sizes, and tonotopic order. Beyond the primary auditory cortex, there are at least three distinct areas with fine-scale tonotopic organization, as well as at least one additional high-frequency field. The arrangement of all of these cortical areas is consistent across subjects. The accuracy of these optical maps was confirmed by microelectrode mapping in the same subjects. This imaging method allows fast mapping of the auditory cortex at high spatial resolution comparable to that provided by conventional microelectrode technique. Although spiking activity is largely responsible for the evoked intrinsic signals, certain features of the optical signal cannot be explained by spiking activity only, and should probably be attributed to other mechanisms inducing metabolic activity, such as subthreshold membrane phenomena.
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Abbreviations: SPL, sound pressure level; CF, characteristic frequency; RF, receptive field; A1, primary auditory cortex; AAF, anterior auditory field; VAF, ventral auditory field; VAAF, ventral anterior auditory field; BF, best frequency.
To whom correspondence may be addressed. E-mail: vkalatsky@uh.edu or merz@phy.ucsf.edu.
Present address: Department of Electrical and Computer Engineering, University of Houston, 4800 Calhoun Road, Building 1, Room N308, Houston, TX 77204-4005.
Author contributions: V.A.K., M.M.M., C.E.S., and M.P.S. designed research; V.A.K. and D.B.P. performed research; V.A.K. analyzed data; and V.A.K., D.B.P., M.M.M., C.E.S., and M.P.S. wrote the paper.
Contributed by Michael M. Merzenich, July 11, 2005
A preliminary report of this work was presented in Kalatsky, V. A. & Stryker M. P. (2002) Soc. Neurosci. Abstr. 354.15 (abstr.).
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0505592102