Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183

• Published in: Cell reports (Cambridge) Vol. 23; no. 13; pp. 3750 - 3758
• Main Authors: Chu, Coco, Moriyama, Saya, Li, Zhi, Zhou, Lei, Flamar, Anne-Laure, Klose, Christoph S.N., Moeller, Jesper B., Putzel, Gregory G., Withers, David R., Sonnenberg, Gregory F., Artis, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.06.2018; Elsevier
• Subjects: accumulation; Animals; anti-microbial; Cell Movement; Citrobacter rodentium - pathogenicity; Cytochrome P450 Family 7 - metabolism; distribution; Enterobacteriaceae Infections - pathology; Enterobacteriaceae Infections - prevention & control; Enterobacteriaceae Infections - veterinary; GPR183; group 3 innate lymphoid cells; Humans; Hydroxycholesterols - chemistry; Hydroxycholesterols - metabolism; Immunity, Innate; Intestinal Mucosa - cytology; Intestinal Mucosa - metabolism; intestine; Ligands; Lymphoid Tissue - cytology; Lymphoid Tissue - metabolism; mesenteric lymph node; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucous Membrane - cytology; Mucous Membrane - metabolism; Receptors, G-Protein-Coupled - antagonists & inhibitors; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Steroid Hydroxylases - deficiency; Steroid Hydroxylases - genetics; Steroid Hydroxylases - metabolism; mesenteric lymph node; intestine; accumulation; GPR183; group 3 innate lymphoid cells; distribution; anti-microbial

The intestinal tract is constantly exposed to various stimuli. Group 3 innate lymphoid cells (ILC3s) reside in lymphoid organs and in the intestinal tract and are required for immunity to enteric bacterial infection. However, the mechanisms that regulate the ILC3s in vivo remain incompletely defined...