Mechanism of norcantharidin intervention in gastric cancer: analysis based on antitumor proprietary Chinese medicine database, network pharmacology, and transcriptomics

• Published in: Chinese medicine Vol. 19; no. 1; pp. 129 - 21
• Main Authors: Zhai, Yiyan, Zhang, Fanqin, Zhou, Jiying, Qiao, Chuanqi, Jin, Zhengsen, Zhang, Jingyuan, Wu, Chao, Shi, Rui, Huang, Jiaqi, Gao, Yifei, Guo, Siyu, Wang, Haojia, Chai, Keyan, Zhang, Xiaomeng, Wang, Tieshan, Sheng, Xiaoguang, Liu, Xinkui, Wu, Jiarui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.09.2024; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Antitumor activity; Antitumor patent Chinese medicine; Apoptosis; Bioinformatics; Cancer; Cell adhesion; Cell cycle; Cell migration; Cell proliferation; Chemotherapy; Ethylenediaminetetraacetic acid; Gastric cancer; Health aspects; Health insurance; Herbal medicine; Medicine, Botanic; Medicine, Chinese; Medicine, Herbal; NF-κB protein; Norcantharidin; Pharmacology; Public health; Quality of life; Radiation therapy; SERPINE 1; Stomach cancer; Traditional Chinese medicine; Transcriptomics; Tumor necrosis factor-α; Tumors; Canada; China; United States > US; Database; Antitumor patent Chinese medicine; Gastric cancer; SERPINE 1

Combining antitumor proprietary Chinese medicine (pCm) with radiotherapy and chemotherapy can effectively improve tumor cure rates and enhance patients' quality of life. Gastric cancer (GC) severely endangers public health. Despite satisfactory therapeutic effects achieved by using antitumor pC...