The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin

• Published in: Chinese medicine Vol. 19; no. 1; pp. 12 - 17
• Main Authors: Hua, Qingzhong, Ren, Lu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.01.2024; BioMed Central; BMC
• Subjects: Acetylation; Antioxidants; Bleomycin; Bone morphogenetic proteins; Ethylenediaminetetraacetic acid; Extracellular matrix; Fibroblasts; Fibrosis; Health aspects; Herbal medicine; Immunofluorescence; Investigations; Liquiritigenin; Lung diseases; Medical innovations; Metabolism; Myofibroblast differentiation; Nrf2; Nuclear transport; Oxidants; Oxidative stress; Phosphorylation; Polyclonal antibodies; Polymerase chain reaction; Pulmonary fibrosis; Reagents; Signal transduction; siRNA; SIRT1; SIRT1 protein; Smad protein; Transcription factors; Transforming growth factor-b1; Transforming growth factors; Western blotting; China; United States > US; Oxidative stress; Pulmonary fibrosis; Liquiritigenin; Nrf2; SIRT1; Myofibroblast differentiation

At present, the treatment options available for idiopathic pulmonary fibrosis are both limited and often come with severe side effects, emphasizing the pressing requirement for innovative therapeutic alternatives. Myofibroblasts, which hold a central role in pulmonary fibrosis, have a close associat...