The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer

• Published in: Scientific reports Vol. 12; no. 1; pp. 5377 - 12
• Main Authors: Haruna, Miya, Ueyama, Azumi, Yamamoto, Yoko, Hirata, Michinari, Goto, Kumiko, Yoshida, Hiroshi, Higuchi, Naoko, Yoshida, Tetsuya, Kidani, Yujiro, Nakamura, Yamami, Nagira, Morio, Kawashima, Atsunari, Iwahori, Kota, Shintani, Yasushi, Ohkura, Naganari, Wada, Hisashi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/250/251; 692/4028/67/1612; 692/4028/67/580; Animal models; Animals; Cancer immunotherapy; Cancer therapies; CCR8 protein; CD8 antigen; Cell culture; Cytotoxicity; Genomes; Homeostasis; Humanities and Social Sciences; Humans; Immune checkpoint inhibitors; Immune response; Immune Tolerance; Immunoregulation; Immunosuppression; Immunotherapy; Lung cancer; Lung Neoplasms - pathology; Lymphocytes; Lymphocytes T; Metastases; Mice; multidisciplinary; Patients; Receptors, CCR8 - metabolism; Science; Science (multidisciplinary); T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tumor-infiltrating lymphocytes; Tumors

Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs h...