Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau

• Published in: Acta neuropathologica communications Vol. 11; no. 1; pp. 160 - 11
• Main Authors: Schweighauser, Manuel, Murzin, Alexey G., Macdonald, Jennifer, Lavenir, Isabelle, Crowther, R. Anthony, Scheres, Sjors H.W., Goedert, Michel
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.10.2023; BioMed Central; BMC
• Subjects: Animals; Brain; Brain - metabolism; Brain diseases; Cryoelectron Microscopy; Cytoskeleton - metabolism; Dementia; Disease Models, Animal; Electron cryo-microscopy; Frontotemporal dementia and parkinsonism linked to chromosome 17; Genetic engineering; Humans; Mice; Mice, Transgenic; Microscopy; Mutation; Nervous system; Neurodegeneration; P301S tau; Parkinson's disease; Sensors; Spinal cord; tau Proteins - metabolism; Tauopathies - metabolism; Transgenic mice; Electron cryo-microscopy; Frontotemporal dementia and parkinsonism linked to chromosome 17; P301S tau; Transgenic mice

Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-EM) to determine the structures of tau filaments from the b...