Transferrin Receptor Is a Specific Ferroptosis Marker

• Published in: Cell reports (Cambridge) Vol. 30; no. 10; pp. 3411 - 3423.e7
• Main Authors: Feng, Huizhong, Schorpp, Kenji, Jin, Jenny, Yozwiak, Carrie E., Hoffstrom, Benjamin G., Decker, Aubrianna M., Rajbhandari, Presha, Stokes, Michael E., Bender, Hannah G., Csuka, Joleen M., Upadhyayula, Pavan S., Canoll, Peter, Uchida, Koji, Soni, Rajesh K., Hadian, Kamyar, Stockwell, Brent R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.03.2020; Elsevier
• Subjects: Animals; Antibodies, Monoclonal - metabolism; Antigens - metabolism; biomarker; Biomarkers - metabolism; cancer; cell death; Cell Line; Cell Line, Tumor; Cell Membrane - drug effects; Cell Membrane - metabolism; ferroptosis; Ferroptosis - drug effects; ferroptosis marker; ferroptosis-specific antibody; Golgi Apparatus - metabolism; Humans; Injections; iron; Mice; Piperazine - pharmacology; Piperazines - pharmacology; Receptors, Transferrin - metabolism; ROS; tissue staining; transferrin receptor; Xenograft Model Antitumor Assays; ferroptosis; cell death; ferroptosis marker; ROS; transferrin receptor; iron; ferroptosis-specific antibody; cancer; biomarker; tissue staining

Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to selectively stain ferroptotic cells in tissue sections to characterize the extent of ferroptosis in animal models or pa...