Drugs with dual-hormone action gain attention in diabetes field

Engineered peptide drugs that simultaneously target two hormone receptors have historically attracted interest among scientists hoping to create new treatments for diabetes. Now, many in the field seem buoyed by new data from a class of diabetes medicines designed to mimic gastrointestinal hormones...

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Published inNature medicine Vol. 19; no. 12; p. 1549
Main Author Hackethal, Veronica
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.12.2013
Nature Publishing Group
Subjects
631/154/51
692/308
692/699/2743/137
Biomedicine
Biomimetic Materials - therapeutic use
Cancer Research
Care and treatment
Diabetes
Diabetes Mellitus - drug therapy
Endocrinology - methods
Endocrinology - trends
Gastrointestinal Agents - therapeutic use
Gastrointestinal hormones
Genetic engineering
Glucagon-Like Peptide-1 Receptor
Hormone receptors
Hormones
Humans
Hypoglycemic Agents - therapeutic use
Incretins - therapeutic use
Infectious Diseases
Metabolic Diseases
Molecular Medicine
Neurosciences
news
Pancreatic beta cells
Peptides
Pharmaceuticals
Physiological aspects
Receptors, Glucagon - agonists
Studies
United States
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Abstract Engineered peptide drugs that simultaneously target two hormone receptors have historically attracted interest among scientists hoping to create new treatments for diabetes. Now, many in the field seem buoyed by new data from a class of diabetes medicines designed to mimic gastrointestinal hormones called incretins, which stimulate insulin release from pancreatic beta cells.
AbstractList Engineered peptide drugs that simultaneously target two hormone receptors have historically attracted interest among scientists hoping to create new treatments for diabetes. Now, many in the field seem buoyed by new data from a class of diabetes medicines designed to mimic gastrointestinal hormones called incretins, which stimulate insulin release from pancreatic beta cells.
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Author Hackethal, Veronica
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Cites_doi 10.1126/scitranslmed.3007218
10.2337/db12-0797
10.2337/db09-0278
10.1111/j.1476-5381.2011.01714.x
10.1074/jbc.M113.512046
10.1038/nm.3009
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References PocaiADiabetes200958225822661:CAS:528:DC%2BD1MXht1yku7jK10.2337/db09-0278
Gault, V.A., Bhat, V.K., Irwin, N. & Flatt, P.R. J. Biol. Chem. doi:10.1074/jbc.M113.512046 (2013).
FinanBNat. Med.201218184718561:CAS:528:DC%2BC38Xhs1CktL7F10.1038/nm.3009
TanTMDiabetes201362113111381:CAS:528:DC%2BC3sXpvFCkur4%3D10.2337/db12-0797
FinanBSci. Transl. Med.20135209ra15110.1126/scitranslmed.3007218
AxelsenLNBr. J. Pharmacol.2012165273627481:CAS:528:DC%2BC38XltVajtbk%3D10.1111/j.1476-5381.2011.01714.x
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Snippet Engineered peptide drugs that simultaneously target two hormone receptors have historically attracted interest among scientists hoping to create new treatments...
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SubjectTerms 631/154/51
692/308
692/699/2743/137
Biomedicine
Biomimetic Materials - therapeutic use
Cancer Research
Care and treatment
Diabetes
Diabetes Mellitus - drug therapy
Endocrinology - methods
Endocrinology - trends
Gastrointestinal Agents - therapeutic use
Gastrointestinal hormones
Genetic engineering
Glucagon-Like Peptide-1 Receptor
Hormone receptors
Hormones
Humans
Hypoglycemic Agents - therapeutic use
Incretins - therapeutic use
Infectious Diseases
Metabolic Diseases
Molecular Medicine
Neurosciences
news
Pancreatic beta cells
Peptides
Pharmaceuticals
Physiological aspects
Receptors, Glucagon - agonists
Studies
Title Drugs with dual-hormone action gain attention in diabetes field
URI https://link.springer.com/article/10.1038/nm1213-1549
https://www.ncbi.nlm.nih.gov/pubmed/24309637
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