Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors

• Published in: Stem cell reports Vol. 3; no. 5; pp. 832 - 840
• Main Authors: Lee, Dongjun, Sykes, Stephen M., Kalaitzidis, Demetrios, Lane, Andrew A., Kfoury, Youmna, Raaijmakers, Marc H.G.P., Wang, Ying-Hua, Armstrong, Scott A., Scadden, David T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.11.2014; Elsevier
• Subjects: Animals; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Cycle Proteins - metabolism; Cells, Cultured; Forkhead Box Protein O3; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; HEK293 Cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins - metabolism; Mechanistic Target of Rapamycin Complex 2; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Mice; Mice, Knockout; Mice, Transgenic; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; NIH 3T3 Cells; Phosphorylation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Protein Binding; Protein Kinase C-alpha - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Rapamycin-Insensitive Companion of mTOR Protein; Receptors, Notch - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism

Central to cellular proliferative, survival, and metabolic responses is the serine/threonine kinase mTOR, which is activated in many human cancers. mTOR is present in distinct complexes that are either modulated by AKT (mTORC1) or are upstream and regulatory of it (mTORC2). Governance of mTORC2 acti...