Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery

• Published in: Journal of experimental & clinical cancer research Vol. 42; no. 1; pp. 117 - 20
• Main Authors: Long, Li, Xiong, Wei, Lin, Fenwang, Hou, Jiazhen, Chen, Guihua, Peng, Taoxing, He, Yihao, Wang, Rui, Xu, Qin, Huang, Yongzhuo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.05.2023; BioMed Central; BMC
• Subjects: Analysis; Animals; Cancer; Care and treatment; CD8-Positive T-Lymphocytes; Colorectal cancer; Colorectal cancer liver metastasis; Colorectal Neoplasms - drug therapy; Cytotoxicity; Dendritic cells; Efficiency; Enzymes; Epithelial-Mesenchymal Transition; Epithelial-mesenchymal transition (EMT); Gastrointestinal diseases; Glycolysis; Health aspects; Humans; Hyaluronic Acid; Immune microenvironment; Kinases; Lactates; Lactic Acid; Liver Neoplasms - drug therapy; Lymphocytes; Metabolism; Metastasis; Mice; Nanoparticles; Proteins; Pyruvate kinase M2 (PKM2); Shikonin; Stem cells; T cells; Transforming growth factors; Tumor Microenvironment; Tumors; China; Immune microenvironment; Glycolysis; Epithelial-mesenchymal transition (EMT); Pyruvate kinase M2 (PKM2); Shikonin; Colorectal cancer liver metastasis

There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis, epithelial-mesenchymal transition (EMT), and immune microenvironment contribute to the progression of CRLM. A main glycolytic enzyme pyruvate Kinase M2 (PKM2) is highly...