Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery - Long, Li; Xiong, Wei; Lin, Fenwang; Hou, Jiazhen; Chen, Guihua; Peng, Taoxing; He, Yihao; Wang, Rui; Xu, Qin; Huang, Yongzhuo (Journal of experimental & clinical cancer research, 2023)
Keywords: Analysis; Animals; Cancer; Care and treatment; CD8-Positive T-Lymphocytes; Colorectal cancer; Colorectal cancer liver metastasis; Colorectal Neoplasms - drug therapy; Cytotoxicity; Dendritic cells; Efficiency; Enzymes; Epithelial-Mesenchymal Transition; Epithelial-mesenchymal transition (EMT); Gastrointestinal diseases; Glycolysis; Health aspects; Humans; Hyaluronic Acid; Immune microenvironment; Kinases; Lactates; Lactic Acid; Liver Neoplasms - drug therapy; Lymphocytes; Metabolism; Metastasis; Mice; Nanoparticles; Proteins; Pyruvate kinase M2 (PKM2); Shikonin; Stem cells; T cells; Transforming growth factors; Tumor Microenvironment; Tumors; China; Immune microenvironment; Glycolysis; Epithelial-mesenchymal transition (EMT); Pyruvate kinase M2 (PKM2); Shikonin; Colorectal cancer liver metastasis