Abnormal Intrastore Calcium Signaling in Chronic Heart Failure

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 39; pp. 14104 - 14109
• Main Authors: Kubalova, Zuzana, Terentyev, Dmitry, Viatchenko-Karpinski, Serge, Nishijima, Yoshinori, Györke, Inna, Terentyeva, Radmila, Daise N. Q. da Cuñha, Sridhar, Arun, Feldman, David S., Hamlin, Robert L., Carnes, Cynthia A., Györke, Sandor, Latorre, Ramon
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.09.2005; National Acad Sciences
• Subjects: Anatomy & physiology; Animals; Biological Sciences; Calcium; Calcium - analysis; Calcium - metabolism; Calcium Signaling; Canines; Cardiac Output, Low - metabolism; Cardiac Output, Low - pathology; Cardiac Output, Low - physiopathology; Chronic Disease; Dogs; Fluorescence; Heart; Heart - physiopathology; Heart failure; Imaging; Lipid bilayers; Muscle Proteins - analysis; Muscle Proteins - metabolism; Myocardium; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Physiological regulation; Receptors; Ryanodine Receptor Calcium Release Channel - metabolism; Sarcoplasmic reticulum; Sarcoplasmic Reticulum - chemistry; Sarcoplasmic Reticulum - metabolism

Diminished Ca release from the sarcoplasmic reticulum (SR) is an important contributor to the impaired contractility of the failing heart. Despite extensive effort, the underlying causes of abnormal SR Ca release in heart failure (HF) remain unknown. We used a combination of simultaneous imaging of...