Distinct CSF biomarker-associated DNA methylation in Alzheimer’s disease and cognitively normal subjects

• Published in: Alzheimer's research & therapy Vol. 15; no. 1; pp. 78 - 19
• Main Authors: Zhang, Wei, Young, Juan I., Gomez, Lissette, Schmidt, Michael A., Lukacsovich, David, Varma, Achintya, Chen, X. Steven, Martin, Eden R., Wang, Lily
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.04.2023; BioMed Central; BMC
• Subjects: Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Biological markers; Biomarkers; Biomarkers - cerebrospinal fluid; Blood; Brain - diagnostic imaging; Brain - pathology; Cerebrospinal fluid proteins; CSF biomarkers; Datasets; Diagnosis; DNA; DNA Methylation; Health aspects; Humans; Measurement; Medical examination; Methylation; Neuroimaging; Neurological research; tau Proteins - cerebrospinal fluid; United States; Alzheimer’s disease; DNA methylation; CSF biomarkers

Growing evidence has demonstrated that DNA methylation (DNAm) plays an important role in Alzheimer's disease (AD) and that DNAm differences can be detected in the blood of AD subjects. Most studies have correlated blood DNAm with the clinical diagnosis of AD in living individuals. However, as t...