Influence of protective isolation on outcome of allogeneic bone marrow transplantation for leukemia

• Published in: Bone marrow transplantation (Basingstoke) Vol. 21; no. 12; pp. 1231 - 1238
• Main Authors: PASSWEG, J. R, ROWLINGS, P. A, SCHAEFER, U. W, SOBOCINSKI, K. A, VOSSEN, J. M, ZHANG, M.-J, HOROWITZ, M. M, ATKINSON, K. A, BARRETT, A. J, GALE, R. P, GRATWOHL, A, JACOBSEN, N, KLEIN, J. P, LJUNGMAN, P, RUSSELL, J. A
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.06.1998
• Subjects: Adolescent; Adult; Air flow; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antibiotic Prophylaxis; Biological and medical sciences; Bone marrow; Bone marrow transplantation; Bone Marrow Transplantation - adverse effects; Bone marrow, stem cells transplantation. Graft versus host reaction; Child; Child, Preschool; Female; Filtration; Gloves; Hematologic and hematopoietic diseases; Histocompatibility antigen HLA; Humans; Hygiene; Infant; Infections; Isolation units; Leukemia; Leukemia - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Mortality; Regression analysis; Regression models; Risk assessment; Stem cell transplantation; Survival; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation, Homologous; Transplants; Human; Postoperative; Prognosis; Treatment efficiency; Leukemia; Homograft; Malignant hemopathy; Transplantation; Infection; Prevention; Bone marrow; Complication; Isolation

Various isolation strategies are used to prevent infections during bone marrow transplantation; data on their efficacy are lacking. We studied whether use of high efficiency particulate air filtration (HEPA) and/or laminar airflow (LAF) units affect transplant-related mortality (TRM) or survival in...