Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis

• Published in: Molecular cell Vol. 62; no. 6; pp. 834 - 847
• Main Authors: Robson, Michael I., de las Heras, Jose I., Czapiewski, Rafal, Lê Thành, Phú, Booth, Daniel G., Kelly, David A., Webb, Shaun, Kerr, Alastair R.W., Schirmer, Eric C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.06.2016; Cell Press
• Subjects: Animals; Cell Differentiation; Cell Line; cell nucleolus; Chromosome Positioning; Down-Regulation; gene expression regulation; Gene Expression Regulation, Developmental; genes; Humans; Ion Channels - genetics; Ion Channels - metabolism; Kinetics; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; muscle development; Muscle Development - genetics; Muscle Fibers, Skeletal - metabolism; muscles; Myoblasts, Skeletal - metabolism; myotubes; Nuclear Envelope - metabolism; nuclear membrane; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; RNA Interference; transcriptomics; Transfection; transmembrane proteins

Whether gene repositioning to the nuclear periphery during differentiation adds another layer of regulation to gene expression remains controversial. Here, we resolve this by manipulating gene positions through targeting the nuclear envelope transmembrane proteins (NETs) that direct their normal rep...