Translocation of Proteins through a Distorted Lipid Bilayer

• Published in: Trends in cell biology Vol. 31; no. 6; pp. 473 - 484
• Main Authors: Wu, Xudong, Rapoport, Tom A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2021; Elsevier BV
• Subjects: Cytosol; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum-Associated Degradation; lipid bilayer; Lipid bilayers; Lipid Bilayers - metabolism; Lipids; membrane distortion; Membranes; Organelles; Protein folding; protein translocation; Protein Transport; Proteins; Saccharomyces cerevisiae Proteins - metabolism; structure; Translocation; lipid bilayer; membrane distortion; structure; endoplasmic reticulum; protein translocation

Membranes surrounding cells or organelles represent barriers to proteins and other molecules. However, specific proteins can cross membranes by different translocation systems, the best studied being the Sec61/SecY channel. This channel forms a hydrophilic, hourglass-shaped membrane channel, with a...