Opioid-Induced Tolerance and Dependence in Mice Is Modulated by the Distance between Pharmacophores in a Bivalent Ligand Series - David J. Daniels; Natalie R. Lenard; Chris L. Etienne; Law, Ping-Yee; Sandra C. Roerig; Portoghese, Philip S. (Proceedings of the National Academy of Sciences - PNAS, 2005)
Keywords: Agonists; Analgesics - pharmacology; Analgesics, Opioid - pharmacology; Animals; Biological Sciences; Chemistry, Pharmaceutical - methods; Dose-Response Relationship, Drug; Drug interactions; Drug tolerance; Lactose tolerance test; Ligands; Male; Mice; Mice, Inbred ICR; Models, Chemical; Models, Statistical; Morphine; Morphine - pharmacology; Morphine dependence; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Narcotic Antagonists - pharmacology; Narcotics; Narcotics - metabolism; Opioid analgesics; Opioid receptors; Pharmacology; Receptors; Receptors, Opioid, delta - chemistry; Receptors, Opioid, mu - chemistry; Rodents; Time Factors